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Meta-Analysis
. 2016 Apr;54(4):1133-6.
doi: 10.1128/JCM.03205-15. Epub 2016 Jan 27.

Diagnostic Performance of Xpert MTB/RIF in Tuberculous Pleural Effusion: Systematic Review and Meta-analysis

Inderpaul Singh Sehgal  1 , Sahajal Dhooria  1 , Ashutosh Nath Aggarwal  1 , Digambar Behera  1 , Ritesh Agarwal  2
Affiliations
Meta-Analysis

Diagnostic Performance of Xpert MTB/RIF in Tuberculous Pleural Effusion: Systematic Review and Meta-analysis

Inderpaul Singh Sehgal et al. J Clin Microbiol. 2016 Apr.

Abstract

A systematic review investigating the role of Xpert MTB/RIF in the diagnosis of tuberculous pleural effusion (TPE) was conducted. The pooled sensitivities and specificities of Xpert MTB/RIF were 51.4% and 98.6%, respectively, with culture used as a reference standard and 22.7% and 99.8%, respectively, with a composite reference standard (CRS) used as the benchmark. Xpert MTB/RIF has low sensitivity but excellent specificity in the diagnosis of TPE.

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Figures

FIG 1
FIG 1
Forest plot of the sensitivity and specificity of Xpert MTB/RIF in tuberculous pleural effusion using a pleural fluid culture reference standard and a CRS. The sensitivity and specificity of each individual studies are represented by a square through which runs a horizontal line (95% confidence interval). TP, true positive; FP, false positive; FN, false negative; TN, true negative.
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