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Comment
. 2016 Jan 27;23(3):186-8.
doi: 10.1128/CVI.00037-16.

Progress toward a Respiratory Syncytial Virus Vaccine

Kathleen M Neuzil  1
Affiliations
Comment

Progress toward a Respiratory Syncytial Virus Vaccine

Kathleen M Neuzil. Clin Vaccine Immunol. .

Abstract

In accompanying papers (P. L. Acosta, M. T. Caballero, and F. P. Polack, Clin Vaccine Immunol 23:189-195, 2016, http://dx.doi.org/10.1128/CVI.00609-15; M. Vissers, I. M. L. Ahout, M. I. de Jonge, and G. Ferwerda, Clin Vaccine Immunol 23:243-245, 2016, http://dx.doi.org/10.1128/CVI.00590-15) in this issue of Clinical and Vaccine Immunology, the history of and immune mechanisms underlying vaccine-enhanced respiratory syncytial virus (RSV) disease and of investigations of mucosal antibodies and their association with viral load in RSV-infected children, respectively, are described. This commentary discusses RSV vaccine candidates, target populations, and the challenges associated with achieving a safe and effective vaccine.

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Figures

FIG 1
FIG 1
RSV vaccine snapshot (reproduced from the PATH website at http://sites.path.org/vaccinedevelopment/respiratory-syncytial-virus-rsv/ [accessed 19 January 2016]). BCG, Mycobacterium bovis BCG; mAb, monoclonal antibody; MVA, modified vaccinia Ankara virus; PIV, parainfluenza virus; SeV, Sendai virus; TBD, to be determined; VLP, virus-like particle.
See this image and copyright information in PMC

Comment on

References

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    1. Acosta PL, Caballero MT, Polack FP. 2016. Brief history and characterization of enhanced respiratory syncytial virus disease. Clin Vaccine Immunol 23:189–195. doi:10.1128/CVI.00609-15. - DOI - PMC - PubMed
    1. Vissers M, Ahout IML, de Jonge MI, Ferwerda G. 2016. Mucosal IgG levels correlate better with respiratory syncytial virus load and inflammation than plasma IgG levels. Clin Vaccine Immunol 23:243–245. doi:10.1128/CVI.00590-15. - DOI - PMC - PubMed
    1. PATH. 2016. Respiratory syncytial virus. Vaccine development against a major cause of childhood respiratory illness. http://sites.path.org/vaccinedevelopment/respiratory-syncytial-virus-rsv/ Accessed 19 January 2016.

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