Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Feb 23;133(8):689-91.
doi: 10.1161/CIRCULATIONAHA.116.021230. Epub 2016 Jan 27.

Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

Stephen C Kolwicz Jr  1 , Sophia Airhart  1 , Rong Tian  2
Affiliations
Editorial

Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

Stephen C Kolwicz Jr et al. Circulation. .
No abstract available

Keywords: Editorials; heart failure; hypertrophy; metabolism.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Ketone metabolism is increased in failing hearts of mice and humans. The major findings of altered ketone body (red) and fatty acid (blue) metabolism from current studies in failing mice and humans are summarized. Decreased fatty acid oxidation was evidenced by a reduction in long-chain acylcarnitines and reduced protein abundance of several enzymes in beta-oxidation (β-ox). Elevations in serum ketone body concentration were matched with alterations in metabolites and enzymes that are consistent with the upregulation of the ketone oxidation pathway. βOHB, beta-hydroxybutyrate; BDH1, mitochondrial beta-hydroxybutyrate dehydrogenase; SCOT, succinyl-CoA:3-oxoacid-CoA transferase; Acac CoA, acetoacetyl CoA; βOHB CoA, beta-hydroxybutyryl CoA; C4-OH carnitine, hydroxybutyrylcarnitine; C2-carnitine, acetyl-carnitine. Green arrow, findings made in mouse heart failure (HF); Yellow arrow, findings made in human HF.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ingwall JS, Weiss RG. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res. 2004;95:135–145. - PubMed
    1. Neubauer S. The failing heart--an engine out of fuel. N Engl J Med. 2007;356:1140–1151. - PubMed
    1. Fukushima A, Milner K, Gupta A, Lopaschuk GD. Myocardial energy substrate metabolism in heart failure : From pathways to therapeutic targets. Curr Pharm Des. 2015;21:3654–3664. - PubMed
    1. Kolwicz SC, Jr., Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 2013;113:603–616. - PMC - PubMed
    1. Aubert G, Martin O, Horton J, Lai L, Vega R, Leone T, Koves T, Gardell S, Kruger M, Hoppel C, Lewandowski E, Crawford P, Muoio D, Kelly D. The failing heart relies on ketone bodies as fuel. Circulation. 2016;133 XX-XXX. - PMC - PubMed