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. 2016 Feb 23;86(8):723-30.
doi: 10.1212/WNL.0000000000002398. Epub 2016 Jan 27.

An investigation into the psychosocial effects of the postictal state

Colin B Josephson  1 , Jordan D T Engbers  1 , Tolulope T Sajobi  1 , Nathalie Jette  1 , Yahya Agha-Khani  1 , Paolo Federico  1 , William Murphy  1 , Neelan Pillay  1 , Samuel Wiebe  2
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An investigation into the psychosocial effects of the postictal state

Colin B Josephson et al. Neurology. .

Abstract

Objective: To determine whether postictal cognitive and behavioral impairment (PCBI) is independently associated with specific aspects of a patient's psychosocial health in those with epilepsy and nonepileptic events.

Methods: We used the University of Calgary's Comprehensive Epilepsy Clinic prospective cohort database to identify patients reporting PCBI. The cohort was stratified into those diagnosed with epilepsy or nonepileptic events at first clinic visit. Univariate comparisons and stepwise multiple logistic regression with backward elimination method were used to identify factors associated with PCBI for individuals with epilepsy and those with nonepileptic events. We then determined if PCBI was independently associated with depression and the use of social assistance when controlling for known risk factors.

Results: We identified 1,776 patients, of whom 1,510 (85%) had epilepsy and 235 had nonepileptic events (13%). PCBI was independently associated with depression in those with epilepsy (odds ratio [OR] 1.73; 95% confidence interval [CI] 1.06-2.83; p = 0.03) and with the need for social assistance in those with nonepileptic events (OR 4.81; 95% CI 2.02-11.42; p < 0.001).

Conclusions: PCBI appears to be significantly associated with differing psychosocial outcomes depending on the patient's initial diagnosis. Although additional research is necessary to examine causality, our results suggest that depression and employment concerns appear to be particularly important factors for patients with PCBI and epilepsy and nonepileptic attacks, respectively.

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Figures

Figure 1
Figure 1. Odds ratio of depression according to postictal cognitive and behavioral impairment (PCBI) status when controlling for variables selected a priori from the literature
AED = antiepileptic drug; CI = confidence interval.
Figure 2
Figure 2. Odds ratio of social assistance as the primary income source according to postictal cognitive and behavioral impairment (PCBI) when controlling for variables selected a priori
CI = confidence interval.
See this image and copyright information in PMC

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