. 2016 Jan 26:4:10.

doi: 10.1186/s40560-016-0128-5. eCollection 2016.

Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan

Tomoki Yamada¹, Tetsuhisa Kitamura², Koichi Hayakawa³, Kazuhisa Yoshiya⁴, Taro Irisawa⁴, Yoshio Abe⁵, Megumi Ishiro⁶, Toshifumi Uejima⁷, Yasuo Ohishi⁸, Kazuhisa Kaneda⁶, Takeyuki Kiguchi⁹, Masashi Kishi¹⁰, Masafumi Kishimoto¹¹, Shota Nakao¹², Tetsuro Nishimura¹³, Yasuyuki Hayashi¹⁴, Takaya Morooka¹⁵, Junichi Izawa¹⁶, Tomonari Shimamoto¹⁶, Toshihiro Hatakeyama¹⁶, Tasuku Matsuyama¹⁶, Takashi Kawamura¹⁶, Takeshi Shimazu⁴, Taku Iwami¹⁶

Affiliations

¹ Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan ; Emergency and Critical Care Medical Center, Osaka Police Hospital, Osaka, Japan.
² Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
³ Department of Emergency and Critical Care Medicine, Kansai Medical University, Takii Hospital, Moriguchi, Japan.
⁴ Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
⁵ Department of Emergency Medicine, Tane General Hospital, Osaka, Japan.
⁶ Department of Critical Care Medicine, Osaka City University, Osaka, Japan.
⁷ Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osaka-Sayama, Japan.
⁸ Osaka Mishima Emergency Critical Care Center, Takatsuki, Japan.
⁹ Critical Care and Trauma Center, Osaka General Medical Center, Osaka, Japan.
¹⁰ Emergency and Critical Care Medical Center, Osaka Police Hospital, Osaka, Japan.
¹¹ Osaka Prefectural Nakakawachi Medical Center of Acute Medicine, Higashi-Osaka, Japan.
¹² Senshu Trauma and Critical Care Center, Osaka, Japan.
¹³ Traumatology and Critical Care Medical Center, National Hospital Organization Osaka National Hospital, Osaka, Japan.
¹⁴ Senri Critical Care Medical Center, Saiseikai Senri Hospital, Suita, Japan.
¹⁵ Emergency and Critical Care Medical Center, Osaka City General Hospital, Osaka, Japan.
¹⁶ Kyoto University Health Service, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501 Japan.

PMID: 26819708
PMCID: PMC4729004
DOI: 10.1186/s40560-016-0128-5

Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan

Tomoki Yamada et al. J Intensive Care. 2016.

. 2016 Jan 26:4:10.

doi: 10.1186/s40560-016-0128-5. eCollection 2016.

Authors

Affiliations

¹ Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan ; Emergency and Critical Care Medical Center, Osaka Police Hospital, Osaka, Japan.
² Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
³ Department of Emergency and Critical Care Medicine, Kansai Medical University, Takii Hospital, Moriguchi, Japan.
⁴ Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
⁵ Department of Emergency Medicine, Tane General Hospital, Osaka, Japan.
⁶ Department of Critical Care Medicine, Osaka City University, Osaka, Japan.
⁷ Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osaka-Sayama, Japan.
⁸ Osaka Mishima Emergency Critical Care Center, Takatsuki, Japan.
⁹ Critical Care and Trauma Center, Osaka General Medical Center, Osaka, Japan.
¹⁰ Emergency and Critical Care Medical Center, Osaka Police Hospital, Osaka, Japan.
¹¹ Osaka Prefectural Nakakawachi Medical Center of Acute Medicine, Higashi-Osaka, Japan.
¹² Senshu Trauma and Critical Care Center, Osaka, Japan.
¹³ Traumatology and Critical Care Medical Center, National Hospital Organization Osaka National Hospital, Osaka, Japan.
¹⁴ Senri Critical Care Medical Center, Saiseikai Senri Hospital, Suita, Japan.
¹⁵ Emergency and Critical Care Medical Center, Osaka City General Hospital, Osaka, Japan.
¹⁶ Kyoto University Health Service, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501 Japan.

PMID: 26819708
PMCID: PMC4729004
DOI: 10.1186/s40560-016-0128-5

Abstract

Background: We established a multi-center, prospective cohort that could provide appropriate therapeutic strategies such as criteria for the introduction and the effectiveness of in-hospital advanced treatments, including percutaneous coronary intervention (PCI), target temperature management, and extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients.

Methods: In Osaka Prefecture, Japan, we registered all consecutive patients who were suffering from an OHCA for whom resuscitation was attempted and who were then transported to institutions participating in this registry since July 1, 2012. A total of 11 critical care medical centers and one hospital with an emergency care department participated in this registry. The primary outcome was neurological status after OHCA, defined as cerebral performance category (CPC) scale.

Results: A total of 688 OHCA patients were documented between July 2012 and December 2012. Of them, 657 were eligible for our analysis. Patients' average age was 66.2 years old, and male patients accounted for 66.2 %. The proportion of OHCAs having a cardiac origin was 50.4 %. The proportion as first documented rhythm of ventricular fibrillation/pulseless ventricular tachycardia was 11.6 %, pulseless electrical activity 23.4 %, and asystole 54.5 %. After hospital arrival, 10.5 % received defibrillation, 90.8 % tracheal intubation, 3.0 % ECPR, 3.5 % PCI, and 83.1 % adrenaline administration. The proportions of 90-day survival and CPC 1/2 at 90 days after OHCAs were 5.9 and 3.0 %, respectively.

Conclusions: The Comprehensive Registry of In-hospital Intensive Care for OHCA Survival (CRITICAL) study will enroll over 2000 OHCA patients every year. It is still ongoing without a set termination date in order to provide valuable information regarding appropriate therapeutic strategies for OHCA patients (UMIN000007528).

Keywords: CRITICAL; Cohort; In-hospital intensive care; Out-of-hospital cardiac arrest; Outcome.

PubMed Disclaimer

Figures

See this image and copyright information in PMC

Cited by

Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan.
Okada Y, Kiguchi T, Irisawa T, Yoshiya K, Yamada T, Hayakawa K, Noguchi K, Nishimura T, Ishibe T, Yagi Y, Kishimoto M, Shintani H, Hayashi Y, Sogabe T, Morooka T, Sakamoto H, Suzuki K, Nakamura F, Nishioka N, Matsuyama T, Sado J, Matsui S, Shimazu T, Koike K, Kawamura T, Kitamura T, Iwami T; CRITICAL Study Group Investigators. Okada Y, et al. J Intensive Care. 2020 May 11;8:34. doi: 10.1186/s40560-020-00451-6. eCollection 2020. J Intensive Care. 2020. PMID: 32426140 Free PMC article.
The Latest in Resuscitation Science Research: Highlights from the American Heart Association's 2017 Resuscitation Science Symposium.
Leary M, McGovern S, Dainty KN, Doshi AA, Blewer AL, Kurz MC, Reynolds JC, Rittenberger JC, Hazinski MF. Leary M, et al. J Am Heart Assoc. 2018 Jan 22;7(2):e008589. doi: 10.1161/JAHA.118.008589. J Am Heart Assoc. 2018. PMID: 29358196 Free PMC article. No abstract available.
Overview and future prospects of out-of-hospital cardiac arrest registries in Japan.
Okada Y, Nakagawa K, Tanaka H, Takahashi H, Kitamura T, Kiguchi T, Nishioka N, Kitamura N, Tagami T, Inoue A, Hifumi T, Sakamoto T, Kuroda Y, Iwami T. Okada Y, et al. Resusc Plus. 2024 Feb 10;17:100578. doi: 10.1016/j.resplu.2024.100578. eCollection 2024 Mar. Resusc Plus. 2024. PMID: 38362506 Free PMC article. Review.
Underlying Cause of Out-of-Hospital Cardiac Arrests in Japan in Survivors Versus Nonsurvivors.
Yoshimura S, Tseng ZH, Yamada T, Nakao S, Yoshiya K, Park C, Nishimura T, Ishibe T, Yamakawa K, Kiguchi T, Kishimoto M, Ninomiya K, Ito Y, Sogabe T, Morooka T, Sakamoto H, Hironaka Y, Onoe A, Matsuyama T, Okada Y, Matsui S, Nishioka N, Kimata S, Kawai S, Makino Y, Zha L, Kiyohara K, Kitamura T, Iwami T; CRITICAL Study Group Investigators. Yoshimura S, et al. J Am Heart Assoc. 2025 May 6;14(9):e036968. doi: 10.1161/JAHA.124.036968. Epub 2025 Apr 16. J Am Heart Assoc. 2025. PMID: 40240947 Free PMC article.
Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm.
Okada Y, Shahidah N, Ng YY, Chia MYC, Gan HN, Leong BSH, Mao DR, Ng WM, Irisawa T, Yamada T, Nishimura T, Kiguchi T, Kishimoto M, Matsuyama T, Nishioka N, Kiyohara K, Kitamura T, Iwami T, Ong MEH. Okada Y, et al. Crit Care. 2023 Sep 12;27(1):351. doi: 10.1186/s13054-023-04636-x. Crit Care. 2023. PMID: 37700335 Free PMC article.

See all "Cited by" articles

References

1. Hazinski MF, Nolan JP, Billi JE, Bottiger BW, Bossaert L, de Caen AR, et al. Part 1: 2010 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation. 2010;122(suppl2):S250–75. doi: 10.1161/CIRCULATIONAHA.110.970897. - DOI - PubMed
1. Ambulance Service Planning Office of Fire and Disaster Management Agency of Japan. Effect of first aid for cardiopulmonary arrest. http://www.fdma.go.jp/neuter/topics/kyukyukyujo_genkyo/h26/01_kyukyu.pdf (Accessed 16 Jun 2015) (in Japanese).
1. The Osaka Utstein Project Committee. The Osaka Utstein Project Homepage. http://www.osakalifesupport.jp/utstein/ (Accessed 16 Jun 2015) (in Japanese).
1. Iwami T, Kawamura T, Hiraide A, Berg RA, Hayashi Y, Nishiuchi T, et al. Effectiveness of bystander-initiated cardiac-only resuscitation for patients with out-of-hospital cardiac arrest. Circulation. 2007;116:2900–7. doi: 10.1161/CIRCULATIONAHA.107.723411. - DOI - PubMed
1. Iwami T, Nichol G, Hiraide A, Hayashi Y, Nishiuchi T, Kajino K, et al. Continuous improvements in “chain of survival” increased survival after out-of-hospital cardiac arrests: a large-scale population-based study. Circulation. 2009;119:728–34. doi: 10.1161/CIRCULATIONAHA.108.802058. - DOI - PubMed

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan

Affiliations

Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous

Abstract

Figures

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous