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Review
. 2015 Dec 17;3(1):ofv202.
doi: 10.1093/ofid/ofv202. eCollection 2016 Jan.

Far East Scarlet-Like Fever: A Review of the Epidemiology, Symptomatology, and Role of Superantigenic Toxin: Yersinia pseudotuberculosis-Derived Mitogen A

A Amphlett  1
Affiliations
Review

Far East Scarlet-Like Fever: A Review of the Epidemiology, Symptomatology, and Role of Superantigenic Toxin: Yersinia pseudotuberculosis-Derived Mitogen A

A Amphlett. Open Forum Infect Dis. .

Abstract

Far East scarlet-like fever (FESLF) is a severe inflammatory disease that occurs sporadically and in outbreaks in Russia and Japan. Far East scarlet-like fever is caused by Yersinia pseudotubuclosis infection, an organism that typically causes self-limiting gastroenteritis in Europe. Studies suggest the ability of Far Eastern strains to produce superantigen toxin Y pseudotuberculosis-derived mitogen A is integral to FESLF pathogenesis. In Europe, human Y pseudotuberculosis infection typically occurs sporadically, in the form of a self-limiting gastroenteritis. In Russia and Japan, outbreaks of Y pseudotuberculosis infection cause severe systemic inflammatory symptoms. This disease variant is called FESLF. Geographical heterogeneity exists between virulence factors produced by European and Far Eastern Y pseudotuberculosis strains, implicating superantigen Y pseudotuberculosis-derived mitogen A (YPMa) in the pathogenesis of FESLF. This article describes the epidemiology and clinical features of FESLF, and it presents the evidence for the role of YPMa in FESLF pathogenesis.

Keywords: Far East scarlet-like fever; Yersinia pseudotuberculosis; Yersinia pseudotuberculosis mitogen A.

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References

    1. Malassez L, Vignal W. On microorganisms of zoological tuberculoses [Sur le microorganisme de la tuberculose zoologique]. Arch Physiol Norm Pathol 1884; 3 Ser. 4: 81–105.
    1. Bottone EJ, Bercovier H, Mollaret HH. Genus XLI. Yersinia. In: Garrity GM, Brenner DJ, Krieg NR, Staley JT, ed. Bergey's Manual of Systematic Bacteriology. 2nd ed. Springer: New York; 2005: pp 838–48.
    1. Tseneva GY, Chesnokova MV, Timofeevich KV et al. . Pseudotuberculosis in the Russian Federation. Adv Exp Med Biol 2012; 954:63–8. - PubMed
    1. Fukushima H, Matsuda Y, Seki R. Geographical heterogeneity between Far East and Western countries in prevalence of the virulence plasmid, the superantigen Yersinia pseudotuberculosis derived mitogen and the high-pathogenicity island among Yersinia pseudotuberculosis strains. J Clin Microbiol 2001; 39:3541–7. - PMC - PubMed
    1. Wuthe HH, Aleksić S, Kwapil S. Yersinia in the European brown hare of Northern Germany. Contrib Microbiol Immunol 1995; 13:51–4. - PubMed

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