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Comment
. 2016 Feb;18(2):139-40.
doi: 10.1038/ncb3304.

A twist in zygotic reprogramming

Daniel M Messerschmidt  1
Affiliations
Comment

A twist in zygotic reprogramming

Daniel M Messerschmidt. Nat Cell Biol. 2016 Feb.

Abstract

The first hours of mammalian embryogenesis are devoted to extensive epigenetic reprogramming. One hallmark is active demethylation of the paternal genome by Tet (ten-eleven translocation) enzymes. However, the process is now shown to be Tet-independent at first, with Tet enzymes only counteracting hitherto underappreciated de novo DNA methylation activity in later zygotic stages.

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  • De novo DNA methylation drives 5hmC accumulation in mouse zygotes.
    Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D'Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P. Amouroux R, et al. Nat Cell Biol. 2016 Feb;18(2):225-233. doi: 10.1038/ncb3296. Epub 2016 Jan 11. Nat Cell Biol. 2016. PMID: 26751286 Free PMC article.

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