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Case Reports
. 2016 Apr-Jun;37(2):278-80.
doi: 10.1080/08897077.2016.1138919.

A delayed injection-site reaction in a patient receiving extended-release naltrexone

Keith Ahamad  1   2   3 , P Todd Korthuis  4   5 , Paula J Lum  6 , Cheyenne Johnson  1 , Evan Wood  1   7
Affiliations
Case Reports

A delayed injection-site reaction in a patient receiving extended-release naltrexone

Keith Ahamad et al. Subst Abus. 2016 Apr-Jun.

Abstract

Background: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection.

Case: The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction.

Discussion: Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.

Keywords: Alcohol use disorder; extended-release naltrexone; injection-site reaction.

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References

    1. Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD. Economic costs of excessive alcohol consumption in the U.S., 2006. Am J Prev Med. 2011;41:516–524. - PubMed
    1. Jonas DE, Amick HR, Feltner C, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis. JAMA. 2014;311:1889–1900. - PubMed
    1. Maisel NC, Blodgett JC, Wilbourne PL, Humphreys K, Finney JW. Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: When are these medications most helpful? Addiction. 2013;108:275–293. - PMC - PubMed
    1. Swift R, Oslin DW, Alexander M, Forman R. Adherence Monitoring in Naltrexone Pharmacotherapy Trials: A Systematic Review. Journal of studies on alcohol and drugs. 2011 Nov;72(6):1012–8. - PMC - PubMed
    1. Warren KR, Hewitt BG. NIAAA: Advancing alcohol research for 40 years. Alcohol Health & Research World. 2010 Jan 1;33(1):5. - PMC - PubMed

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