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. 2016:1406:181-7.
doi: 10.1007/978-1-4939-3444-7_15.

A Novel Collagen Dot Assay for Monitoring Cancer Cell Migration

Vincent M Alford  1 , Eric Roth  1 , Qian Zhang  1 , Jian Cao  2
Affiliations

A Novel Collagen Dot Assay for Monitoring Cancer Cell Migration

Vincent M Alford et al. Methods Mol Biol. 2016.

Abstract

Cell migration is a critical determinant of cancer invasion and metastasis. Drugs targeting cancer cell migration have been hindered due to the lack of effective assays for monitoring cancer cell migration. Here we describe a novel method to microscopically monitor cell migration in a quantitative fashion. This assay can be used to study genes involved in cancer cell migration, as well as screening anticancer drugs that target this cellular process.

Keywords: Microscope; Migration; Non-tissue culture 96-well plate; Two-dimensional culture; Type I collagen.

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