Action of mycosubtilin, an antifungal antibiotic of Bacillus subtilis, on the cell membrane of Saccharomyces cerevisiae
Affiliations
- PMID: 2682141
Item in Clipboard
Action of mycosubtilin, an antifungal antibiotic of Bacillus subtilis, on the cell membrane of Saccharomyces cerevisiae
Microbios.
1989.
Abstract
Mycosubtilin, an antibiotic of the iturin group, inhibits the growth of Saccharomyces cerevisiae by a fungicidal action. Increasing concentrations of mycosubtilin decrease the incorporation of radioactive precursors into proteins, RNA and polysaccharides without specificity. Yeast spheroplasts are lysed by mycosubtilin. Its action on the cytoplasmic membrane induces important modifications of the membrane permeability: nucleotides, proteins and lipids are released from the cells. These releases increase with increasing concentrations of mycosubtilin.
Similar articles
-
Action of antifungal peptidolipids from Bacillus subtilis on the cell membrane of Saccharomyces cerevisiae.J Antibiot (Tokyo). 1984 Feb;37(2):172-7. doi: 10.7164/antibiotics.37.172. J Antibiot (Tokyo). 1984. PMID: 6423598
-
Unique mechanism of action of an antifungal antibiotic RI-331.Drugs Exp Clin Res. 1988;14(7):467-72. Drugs Exp Clin Res. 1988. PMID: 3071450
-
Antifungal activity upon Saccharomyces cerevisiae of iturin A, mycosubtilin, bacillomycin L and of their derivatives; inhibition of this antifungal activity by lipid antagonists.J Antibiot (Tokyo). 1979 Aug;32(8):828-33. doi: 10.7164/antibiotics.32.828. J Antibiot (Tokyo). 1979. PMID: 387691
-
Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae.Microbiol Rev. 1995 Sep;59(3):345-86. doi: 10.1128/mr.59.3.345-386.1995. Microbiol Rev. 1995. PMID: 7565410 Free PMC article. Review.
-
Genomic and genetic approaches for the identification of antifungal drug targets.Infect Disord Drug Targets. 2008 Mar;8(1):2-15. doi: 10.2174/187152608784139613. Infect Disord Drug Targets. 2008. PMID: 18473903 Review.
Cited by
-
Perception of Biocontrol Potential of Bacillus inaquosorum KR2-7 against Tomato Fusarium Wilt through Merging Genome Mining with Chemical Analysis.Biology (Basel). 2022 Jan 14;11(1):137. doi: 10.3390/biology11010137. Biology (Basel). 2022. PMID: 35053135 Free PMC article.
-
Deciphering the nature and statistical optimization of antimicrobial metabolites of two endophytic bacilli.AMB Express. 2025 Jan 13;15(1):10. doi: 10.1186/s13568-024-01811-3. AMB Express. 2025. PMID: 39806214 Free PMC article.
-
Ultraviolet (IUV) and mass spectrometry (IMS) imaging for the deconvolution of microbial interactions.BMC Syst Biol. 2018 Nov 20;12(Suppl 5):99. doi: 10.1186/s12918-018-0617-3. BMC Syst Biol. 2018. PMID: 30458793 Free PMC article.
-
Sequence specific stabilization of a linear analog of the antifungal lipopeptide iturin A2 by sodium during low energy electrospray ionization mass spectrometry conditions.J Am Soc Mass Spectrom. 2001 May;12(5):505-16. doi: 10.1016/S1044-0305(01)00232-X. J Am Soc Mass Spectrom. 2001. PMID: 11349948
-
Bioinformatics Modelling and Metabolic Engineering of the Branched Chain Amino Acid Pathway for Specific Production of Mycosubtilin Isoforms in Bacillus subtilis.Metabolites. 2022 Jan 24;12(2):107. doi: 10.3390/metabo12020107. Metabolites. 2022. PMID: 35208182 Free PMC article.