Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar 23;28(12):2417-20.
doi: 10.1002/adma.201504527. Epub 2016 Jan 29.

Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses

Matthew B Applegate  1 , Benjamin P Partlow  1 , Jeannine Coburn  1 , Benedetto Marelli  1 , Christopher Pirie  2 , Roberto Pineda  3 , David L Kaplan  1 , Fiorenzo G Omenetto  1   4
Affiliations

Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses

Matthew B Applegate et al. Adv Mater. .

Abstract

A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin-doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography.

Keywords: ocular prosthesis; photocrosslinking; silk.

PubMed Disclaimer

Publication types

LinkOut - more resources