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. 2016 Jan 29:16:12.
doi: 10.1186/s12876-016-0425-4.

A potential anatomic subtype of short bowel syndrome: a matched case-control study

Wencheng Kong  1 , Jian Wang  2 , Rongchao Ying  1 , Yousheng Li  3   4 , Huicheng Jin  1 , Qi Mao  2 , Danhua Yao  2 , Mingxiao Guo  5
Affiliations

A potential anatomic subtype of short bowel syndrome: a matched case-control study

Wencheng Kong et al. BMC Gastroenterol. .

Abstract

Background: Fundamental researches suggest that ileum presents greater adaptive potential than the jejunum. However, few studies estimate the association between ileum and adaptive potential in human. To discover the association, we conducted this matched case-control study.

Methods: A 1:2 pair-matched, case-control study was conducted from January 1, 2001 to January 1, 2015 in Intestinal Rehabilition and Transplant Center. The case group was ileum predominated (IP) group and the control group was jejunum predominated (JP) group. Demographic data, medical history and progression of each patient were collected.

Results: There were 24 IP cases and 48 JP controls in this study. The cumulative probabilities of parenteral nutrition (PN) weaning in IP group were higher than that in JP group. The Bristol stool scale scores of IP group were lower than that of JP group at third month. The Cox proportional hazards regression model confirmed that IP had a higher odds of PN weaning (OR = 2.69; 95 % CI: 1.27, 5.70, p = 0.01) as compared with JP group. The conditional logistic regression with 1:2 matching also confirmed IP group had a higher odds (OR = 4.84; 95 % CI: 2.02, 11.56, p <0.01).

Conclusions: Our results indicated that ileum presents greater adaptive potential than the jejunum in nutrition and fluid absorption. And a potential anatomic subtype of short bowel syndrome was proposed. Further research need to be conducted to more fully understand the adaptive potential of ileum besides nutrition and fluid absorption.

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Figures

Fig. 1
Fig. 1
Schematic illustration of treatment procedure of short bowel syndrome and follow-up
Fig. 2
Fig. 2
Flowchart of patient inclusion and exclusion. P-J syndrome, Peutz-Jeghers syndrome
Fig. 3
Fig. 3
Cumulative probabilities of PN weaning in IP group and JP group during follow-up
Fig. 4
Fig. 4
Bristol stool scale scores of IP group and JP group during follow-up. * p = 0.003
Fig. 5
Fig. 5
Intestinal anatomic subtype of short bowel syndrome: Type 3a, the main remnant intestine is jejunum; Type 3b, the main remnant intestine is ileum. The black line shows the anastomosis
See this image and copyright information in PMC

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