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Review
. 2016;15(5):621-7.
doi: 10.1080/15384101.2016.1141841.

BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer

Maja Sedic  1   2   3 , Charlotte Kuperwasser  1   2   3
Affiliations
Review

BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer

Maja Sedic et al. Cell Cycle. 2016.

Abstract

Over the past 20 years tremendous progress has been made in understanding the function of BRCA1 gene products. Yet one question still remains: why is mutation of BRCA1 typically associated with preferential development of breast and ovarian cancers and not tumors in other tissues? Here we discuss recent evidence documenting the effect of BRCA1-haploinsufficiency in different cells and tissues and synthesize a model for how mutations in a single BRCA1 allele in human cells might preferentially confer increased cancer risk in breast epithelial cells.

Keywords: BRCA1; haploinsufficiency; tumor suppression.

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References

    1. Narod SA, Foulkes WD. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 2004; 4:665-76; PMID:15343273; http://dx.doi.org/10.1038/nrc1431 - DOI - PubMed
    1. Yoshida K, Miki Y. Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell-cycle in response to DNA damage. Cancer Sci 2004; 95(11):866-71; PMID:15546503; http://dx.doi.org/10.1111/j.1349-7006.2004.tb02195.x - DOI - PMC - PubMed
    1. Zhang J, Powell SN. The role of the BRCA1 tumor suppressor in DNA double-strand break repair. Mol. Cancer Res. 2005; 3(10):531; PMID:16254187 - PubMed
    1. Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 2006; 34(5):1416-26; PMID:16522651; http://dx.doi.org/10.1093/nar/gkl010 - DOI - PMC - PubMed
    1. Huen MSY, Sy SMH, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Bio 2010; 11:136-48; http://dx.doi.org/10.1038/nrm2831 - DOI - PMC - PubMed

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