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. 2016 Feb 24;55(9):3187-91.
doi: 10.1002/anie.201511624. Epub 2016 Jan 28.

Silver-Mediated Intermolecular 1,2-Alkylarylation of Styrenes with α-Carbonyl Alkyl Bromides and Indoles

Xuan-Hui Ouyang  1 , Ren-Jie Song  1 , Ming Hu  1 , Yuan Yang  1 , Jin-Heng Li  2   3
Affiliations

Silver-Mediated Intermolecular 1,2-Alkylarylation of Styrenes with α-Carbonyl Alkyl Bromides and Indoles

Xuan-Hui Ouyang et al. Angew Chem Int Ed Engl. .

Abstract

A new iron-facilitated silver-mediated radical 1,2-alkylarylation of styrenes with α-carbonyl alkyl bromides and indoles is described, and two new C-C bonds were generated in a single step through a sequence of intermolecular C(sp(3)-Br functionalization and C(sp(2))-H functionalization across the alkenes. This method provides an efficient access to alkylated indoles with broad substrate scope and excellent selectivity.

Keywords: C−H functionalization; alkenes; heterocycles; iron; silver.

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