Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Nov 1;8(11):15100-5.
eCollection 2015.

Expression of galectin-9 mRNA in hepatocellular carcinoma

Yong Liang  1 , Jiayu Chen  1 , Yanzi Zhang  2 , Wei Zhang  3
Affiliations

Expression of galectin-9 mRNA in hepatocellular carcinoma

Yong Liang et al. Int J Clin Exp Pathol. .

Abstract

Liver cancer, with a very high prevalence, is one of the most common causes of death worldwide. Galectin-9, a semi-galactoside-binding protein, was demonstrated to be involved in the formation and metastasis processes of tumors such as breast cancer, and has significant impact on the development and prognosis of tumor. In this study, 90 cases of liver cancer patients who had liver cancer resection surgery treatment, were selected. Samples of liver cancer tissues and cancer-adjacent tissues from the surgery resection of liver cancer patients, which also confirmed by pathology after operation as specimens, were obtained to detect the expression level of Galectin-9 mRNA. The comparing results showed that there were significant differences between the expression of Galectin-9 mRNA in cancer-adjacent tissues and that in cancer tissues (P < 0.05), in terms of pathology differentiation, TNM, and recurrence transfer aspects. However, there were no obvious correlations with gender, age, the size of tumor, and HBsAg. The expression of Galectin-9 mRNA has a close relationship with pathological differentiation, TNM, and recurrence metastasis. Our data presented here provide theoretical basis for new target of liver cancer diagnosis as well as potential prognosis.

Keywords: Galectin-9 mRNA; cancer-adjacent tissues; expression; liver cancer tissues.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Electrophoresis of galectin-9 mRNA in cancer-adjacent tissues and cancer tissues.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • The emerging role of galectins in high-fatality cancers.
    Dubé-Delarosbil C, St-Pierre Y. Dubé-Delarosbil C, et al. Cell Mol Life Sci. 2018 Apr;75(7):1215-1226. doi: 10.1007/s00018-017-2708-5. Epub 2017 Nov 8. Cell Mol Life Sci. 2018. PMID: 29119229 Free PMC article. Review.
  • Galectin-9 in Gastroenterological Cancer.
    Morishita A, Oura K, Tadokoro T, Shi T, Fujita K, Tani J, Atsukawa M, Masaki T. Morishita A, et al. Int J Mol Sci. 2023 Mar 24;24(7):6174. doi: 10.3390/ijms24076174. Int J Mol Sci. 2023. PMID: 37047155 Free PMC article. Review.

References

    1. Liu YM, Chen Y, Li JZ, Gong JP. Up-regulation of Galectin-9 in vivo results in immunosuppressive effects and prolongs survival of liver allograft in rats. Immunol Lett. 2014;162:217–22. - PubMed
    1. Dolina JS, Braciale TJ, Hahn YS. Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Hepatology. 2014;59:1351–65. - PMC - PubMed
    1. Ju Y, Shang X, Liu Z, Zhang J, Li Y, Shen Y, Liu Y, Liu C, Liu B, Xu L, Wang Y, Zhang B, Zou J. The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis. Mol Immunol. 2014;58:85–91. - PubMed
    1. Gu CJ, Wu H, Sheng CY, Ni QC. [Expression and prognostic value of galectin-9 in hepatocellular carcinoma patients] . Zhonghua Yi Xue Za Zhi. 2013;93:2025–8. - PubMed
    1. Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R, Randall JA, McMahan R, Zimmerman MA, Rangachari M, Dobrinskikh E, Busson P, Polyak SJ, Hirashima M, Rosen HR. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One. 2010;5:e9504. - PMC - PubMed