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Case Reports
. 2015 Nov 1;8(11):15312-5.
eCollection 2015.

Langerhans cell sarcoma arising from the root of tongue: a rare case

Jian-Jun Ren  1 , Yu Zhao  1 , Ming-Juan Liu  2 , Guo Liu  1 , Fei Chen  1
Affiliations
Case Reports

Langerhans cell sarcoma arising from the root of tongue: a rare case

Jian-Jun Ren et al. Int J Clin Exp Pathol. .

Abstract

Langerhans cell sarcoma (LCS), a rare malignant disease with markedly malignant cytological features and poor outcome, originates from Langerhans cells and most commonly affects the lymph nodes, skin, and bone. This paper presents the case of a 58-year-old female with LCS at the root of her tongue, with neither local recurrence nor distant metastasis observed during 47 months of follow up following radiotherapy for more than one month after complete tumor resection. Histological and immunophenotypic tests revealed that the malignant tumor cells were positive for S-100 protein, CD1a, and LCA, and partially positive for CD3ε. By contrast, the tumor cells were negative for langenin, CD30, HMB45, PCK, CK5/6, and P63. Their Ki-67proliferation index ranged from 30% to 40%. This neoplasm was diagnosed as LCS according to the classification of WHO2008. This work is the first report on LCS arising from the root of tongue. This rare case may serve as a reference for future clinical studies.

Keywords: Langerhans cell sarcoma; immunohistochemical staining; radiotherapy; tongue.

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Figures

Figure 1
Figure 1
Hematoxylin-eosin staining of LCS (100×).
Figure 2
Figure 2
LCS tumor cells expressed S-100 protein (400×).
Figure 3
Figure 3
LCS tumor cells expressed LCA (400×).
Figure 4
Figure 4
LCS tumor cells expressed CD1a (400×).
Figure 5
Figure 5
LCS tumor cells partially expressed CD3ε (400×).
Figure 6
Figure 6
Ki-67proliferation index ranged from 30%~40% (400×).
See this image and copyright information in PMC

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