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. 2016 Jan 28:26:1.
doi: 10.1186/s12610-015-0028-x. eCollection 2016.

Low serum insulin-like growth factor-1 in patients with erectile dysfunction

Alper Otunctemur  1 , Emin Ozbek  1 , Suleyman Sahin  1 , Levent Ozcan  2 , Murat Dursun  1 , Emre Can Polat  3 , Mustafa Cekmen  4 , Ozgur Doga Ozsoy  4 , Mustafa Erkoc  1 , Eyup Danis  1 , Muammer Bozkurt  1
Affiliations

Low serum insulin-like growth factor-1 in patients with erectile dysfunction

Alper Otunctemur et al. Basic Clin Androl. .

Abstract
in English, French

Objective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED.

Materials and methods: All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated.

Results: The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01).

Conclusion: In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.

Objectifs: La dysfonction endothéliale et les altérations vasculaires jouent un rôle crucial dans la pathogenèse de la dysfonction érectile (DE). L’Insulin-like Growth Factor-1 (IGF-1) est l’un des facteurs de croissance qui ont un vaste champ d’effets biologiques. IGF-1 est un médiateur important de la croissance, différentiation et transformation cellulaires dans différents tissus. Le but de la présente étude était de rechercher une association entre les taux d’IGF-1 et la dysfonction érectile.

Matériel et méthodes: La dysfonction érectile a été évaluée chez tous les hommes, constitués en 2 groupes : 80 patients souffrant de DE depuis plus d’un an, et 80 sujets sans DE recrutés comme groupe témoin dans l’étude. Le diagnostic de DE était basé sur le score 5 de l’Index International de la Fonction Erectile. Les taux d’IGF-1 ont été mesurés par immunodosage automatisé par chemiluminescence. La relation entre les taux d’IGF-1 et le score de la DE a été statistiquement évaluée.

Résultats: L’âge moyen des patients du groupe DE était de 60.4±11.3 ans et de 55.4±9.6 dans le groupe témoin. Les taux plasmatiques d’IGF-1 étaient significativement plus bas dans le groupe DE que chez les témoins (respectivement 96.5±38.3 et 132.5±53.3 ng/mL, P < 0.001). Les taux d’IGF-1 étaient positivement corrélés au score de la DE (r = 0.623, P < 0.01).

Conclusions: Nos résultats indiquent que les taux sériques d’IGF-1 sont associés à une dysfonction endothéliale qui prédit la DE. L’IGF-1 sérique apparaît être un prédicteur spécifique de la DE, et il pourrait être utilisé pour une prédiction précoce de la DE dans la population masculine.

Keywords: Endothelial dysfunction; Erectile dysfunction; Insulin-like growth factor-1; International Index of Erectile Function Score-5.

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Figures

Fig. 1
Fig. 1
Distributions of IGF-1 levels according to the degree of erectile dysfunction (ED). Values are means (±SD) of IGF-1: 132.5 ± 53.3 [no; n = 80], 125.1 ± 33.2 [mild; n = 29], 98.6 ± 25.1 [mild-moderate; n = 24], 79.6 ± 20.2 [moderate; n = 16] and 41.1 ± 15.3 [severe; n = 11], respectively, p < 0.001
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