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Review
. 2013 Oct 21;3(4):356-71.
doi: 10.3390/diagnostics3040356.

Functional Imaging in Diagnostic of Orthopedic Implant-Associated Infections

Inga Potapova  1
Affiliations
Review

Functional Imaging in Diagnostic of Orthopedic Implant-Associated Infections

Inga Potapova. Diagnostics (Basel). .

Abstract

Surgeries' sterile conditions and perioperative antibiotic therapies decrease implant associated infections rates significantly. However, up to 10% of orthopedic devices still fail due to infections. An implant infection generates a high socio-economic burden. An early diagnosis of an infection would significantly improve patients' outcomes. There are numerous clinical tests to diagnose infections. The "Gold Standard" is a microbiological culture, which requires an invasive sampling and lasts up to several weeks. None of the existing tests in clinics alone is sufficient for a conclusive diagnosis of an infection. Meanwhile, there are functional imaging modalities, which hold the promise of a non-invasive, quick, and specific infection diagnostic. This review focuses on orthopedic implant-associated infections, their pathogenicity, diagnosis and functional imaging.

Keywords: diagnostic imaging; orthopedic implant associated infections.

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Figures

Figure 1
Figure 1
Biofilm formation (reprinted from [20] with permission from Elsevier®).
Figure 2
Figure 2
Flow chart of infection diagnosis in clinics.
Figure 3
Figure 3
Criteria of an ideal radiopharmaceutical.
See this image and copyright information in PMC

References

    1. Nelson C.L., McLaren A.C., McLaren S.G., Johnson J.W., Smeltzer M.S. Is aseptic loosening truly aseptic? Clin. Orthop. Related Res. 2005;437:25–30. - PubMed
    1. Biant L.C., Bruce W.J., van der Wall H., William R.W. Infection or allergy in the painful metal-on-metal total hip arthroplasty? J. Arthroplasty. 2010;25:334–336. - PubMed
    1. Bauer T.W., Schils J. The pathology of total joint arthroplasty. II. Mechanisms of implant failure. Skeletal Radiol. 1999;28:483–497. doi: 10.1007/s002560050552. - DOI - PubMed
    1. Dunne W.M., Jr. Bacterial adhesion: Seen any good biofilms lately? Clin. Microbiol. Rev. 2002;15:155–166. doi: 10.1128/CMR.15.2.155-166.2002. - DOI - PMC - PubMed
    1. Harris L.G., Richards R.G. Staphylococci and implant surfaces: A review. Injury. 2006;37:S3–S14. doi: 10.1016/j.injury.2006.04.003. - DOI - PubMed

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