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Review
. 2016 Apr 10;373(2):156-63.
doi: 10.1016/j.canlet.2016.01.004. Epub 2016 Jan 27.

The role of IL-11 in immunity and cancer

Dixon H Xu  1 , Ziwen Zhu  2 , Mark R Wakefield  2 , Huaping Xiao  3 , Qian Bai  2 , Yujiang Fang  4
Affiliations
Review

The role of IL-11 in immunity and cancer

Dixon H Xu et al. Cancer Lett. .

Abstract

Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that utilizes the GP-130 signaling pathway shared by other cytokines of the same family. Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a proinflammatory cytokine, suggesting its complex role in immune response. In recent years, IL-11 has an emerging role in various inflammation-associated cancers. In this review, we aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various cancers, and to provide a therapeutic perspective of strategies utilized to interfere IL-11 signaling in cancer cells.

Keywords: Cancer; Cytokine; IL-11; Immune response.

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