[Clinical evaluation of Hydiphen in the treatment of endogenous depression]

Abstract

The antidepressive effect of Hydiphen was evaluated and compared with imipramine in patients with endogenous depression. The Hydiphen group consisted of 23, and imipramine group of 22 subjects. The evaluation was made using psychometric scales, orthostatic test, ecg, and laboratory tests before treatment as well as during and after the clinical trial. The results proved the antidepressive effect of Hydiphen, in particular its influence on psychomotor activity, and on both mood and anxiety. In comparison to imipramine Hydiphen's++' influence on vegetative symptoms was less pronounced and the drug showed less cardiotoxicity.