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. 2016 May;51(5):705-12.
doi: 10.1038/bmt.2015.320. Epub 2016 Feb 1.

Prevalence and determinants of fatigue in patients with moderate to severe chronic GvHD

A Im  1 , S A Mitchell  2 , S M Steinberg  3 , L Curtis  4 , A Berger  5 , K Baird  6 , Z Kuzmina  7 , G Joe  8 , L E Comis  8 , M Juckett  9 , D Avila  4 , J Baruffaldi  10 , L Masuch  4 , F Pirsl  4 , S Z Pavletic  4
Affiliations

Prevalence and determinants of fatigue in patients with moderate to severe chronic GvHD

A Im et al. Bone Marrow Transplant. 2016 May.

Abstract

Although fatigue is common after allogeneic hematopoietic cell transplantation, little is known about fatigue in patients with chronic GvHD (cGvHD). The aim of this study was to explore factors associated with fatigue in cGvHD. Data were drawn from a sequentially recruited, cross-sectional study of adults with moderate or severe cGvHD (n=263). Respondents were classified as fatigued or not fatigued based on their response to a single item regarding loss of energy from the Lee cGvHD Symptom Scale. In univariate analysis, factors significantly associated with fatigue included performance status, number of prior cGvHD therapies, cGvHD symptom bother, self-assessed physical and mental health, nutritional status, walk velocity and self-reported physical activity. There were no significant associations between fatigue and disease-related cGvHD variables. Multivariable logistic regression demonstrated that being less active and having pulmonary and/or muscle/joint symptoms were independently associated with fatigue. In conclusion, clinically significant fatigue was prevalent in more than one-third of subjects with cGvHD, and was disabling. Absence of association with measures of cGvHD severity underscores the need to elucidate the pathogenesis of fatigue and its relationship with inflammatory activity. Pulmonary and muscle/joint symptoms and physical inactivity represent potential targets for intervention in clinical studies.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
SF 36 PCS score, SF 36 MCS score, and vitality subscale score in fatigued vs. not fatigued patients.
See this image and copyright information in PMC

References

    1. Baird K, Pavletic SZ. Chronic graft versus host disease. Curr Opin Hematol 2006; 13: 426–435. - PubMed
    1. Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus-host disease. Biol Blood Marrow Transplant 2003; 9: 215–233. - PubMed
    1. Pavletic SZ, Fowler DH. Are we making progress in GVHD prophylaxis and treatment? Hematology Am Soc Hematol Educ Program 2012; 2012: 251–264. - PubMed
    1. Arai S, Arora M, Wang T, Spellman SR, He W, Courier DR et al. Graft-vs-Host Disease Working Committee of the CIBMTR. Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant 2015; 21: 266–274. - PMC - PubMed
    1. Dignan FL, Amrolia P, Clark A, Cornish J, Jackson G, Mahendra P et al. Haemato-oncology Task Force of British Committee for Standards in Haematology. British Society for Blood and Marrow Transplantation. Diagnosis and management of chronic graft-versus-host disease. Br J Haematol 2012; 158: 46–61. - PubMed