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Randomized Controlled Trial
. 2016 Apr;38 Suppl 1(Suppl 1):E1974-80.
doi: 10.1002/hed.24362. Epub 2016 Feb 1.

Intraoperative goal-directed hemodynamic management in free tissue transfer for head and neck cancer

William R Hand  1 , William D Stoll  1 , Matthew D McEvoy  2 , Julie R McSwain  1 , Clark D Sealy  3 , Judith M Skoner  4 , Joshua D Hornig  4 , Paul A Tennant  5 , Bethany Wolf  6 , Terry A Day  4
Affiliations
Randomized Controlled Trial

Intraoperative goal-directed hemodynamic management in free tissue transfer for head and neck cancer

William R Hand et al. Head Neck. 2016 Apr.

Abstract

Background: The purpose of this study was to determine the effect of algorithmic physiologic management on patients undergoing head and neck free tissue transfer and reconstruction.

Methods: Ninety-four adult patients were randomized to treatment and control groups. The blood pressure of the control group was managed consistent with contemporary standards. The treatment group was managed using an algorithm based on blood pressure and calculated physiologic values derived from arterial waveform analysis. Primary outcome was intensive care unit (ICU) length of stay.

Results: ICU length of stay was decreased in the treatment group (33.7 vs 58.3 hours; p = .026). The complication rate was not increased in the treatment group.

Conclusion: The goal-directed hemodynamic management algorithm decreased the ICU length of stay. Judicious use of vasoactive drugs and goal-directed fluid administration has a role in improving perioperative outcomes for patients undergoing head and neck free tissue transfer. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1974-E1980, 2016.

Keywords: critical care; free tissue transfer; goal-directed therapy; hemodynamics; length of stay.

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Figures

FIGURE 1.
FIGURE 1.
Goal-directed therapy algorithm directed by utilizing calculated physiologic parameters based on the arterial waveform. MAP, mean arterial pressure; SVV, stroke volume variation; CI, cardiac index; IVF, intravenous fluid; SVR, systemic vascular resistance.
FIGURE 2.
FIGURE 2.
Consolidated Standards of Reporting Trails diagram showing enrollment and disposition.
FIGURE 3.
FIGURE 3.
Boxplot showing intensive care unit (ICU) length of stay (in hours) in treatment and control groups based on intention-to-treat analysis.
See this image and copyright information in PMC

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