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Comparative Study
. 2016 Apr;84(4):334-6.
doi: 10.1016/j.diagmicrobio.2015.12.012. Epub 2015 Dec 17.

Establishing the validity of different susceptibility testing methods to evaluate the in vitro activity of amoxicillin-clavulanate against Escherichia coli

Díez-Aguilar María  1 , Morosini María-Isabel  1 , Conejo María-Carmen  2 , Pascual Álvaro  3 , Calvo Jorge  4 , Martínez-Martínez Luis  5 , Marco Francesc  6 , Vila Jordi  6 , Ortega Adriana  7 , Oteo Jesús  7 , Cantón Rafael  8
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Comparative Study

Establishing the validity of different susceptibility testing methods to evaluate the in vitro activity of amoxicillin-clavulanate against Escherichia coli

Díez-Aguilar María et al. Diagn Microbiol Infect Dis. 2016 Apr.

Abstract

Amoxicillin-clavulanate MICs of 160 Escherichia coli isolates with characterized resistance mechanisms were obtained by 2 MIC gradient strip brands, 3 automated systems, and reference ISO microdilution method using EUCAST (fixed 2μg/mL clavulanate) and CLSI (2:1 ratio) criteria. Discrepancies, mainly obtained with gradient strips, lead to an essential agreement range of 76.2-92.5.

Keywords: Amoxicillin-clavulanate; Automated systems; Escherichia coli; MIC-gradient strips.

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