Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Jacqueline N Crawley¹, Wolf-Dietrich Heyer², Janine M LaSalle³

Affiliations

¹ MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA. Electronic address: crawley@ucdavis.edu.
² Department of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA.
³ MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA; Department of Medical Microbiology and Immunology and Genome Center, University of California Davis, Davis, CA 95616, USA.

PMID: 26830258
PMCID: PMC4769654
DOI: 10.1016/j.tig.2016.01.001

Review

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Jacqueline N Crawley et al. Trends Genet. 2016 Mar.

. 2016 Mar;32(3):139-146.

doi: 10.1016/j.tig.2016.01.001. Epub 2016 Jan 29.

Authors

Jacqueline N Crawley¹, Wolf-Dietrich Heyer², Janine M LaSalle³

Affiliations

¹ MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA. Electronic address: crawley@ucdavis.edu.
² Department of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA.
³ MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA; Department of Medical Microbiology and Immunology and Genome Center, University of California Davis, Davis, CA 95616, USA.

PMID: 26830258
PMCID: PMC4769654
DOI: 10.1016/j.tig.2016.01.001

Abstract

Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.

Keywords: DNA repair; autism; cancer; chromatin remodeling; gene; signaling pathway.

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References

1. Lord C, Bishop SL. Recent advances in autism research as reflected in DSM-5 criteria for autism spectrum disorder. Ann Rev Clin Psychol. 2015;11:53–70. - PubMed
1. Bourgeron T. From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nature Reviews. 2015;16:551–563. - PubMed
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1. De Rubeis S, et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature. 2014;515:209–215. - PMC - PubMed
1. Geschwind DH, State MW. Gene hunting in autism spectrum disorder: on the path to precision medicine. Lancet Neurol. 2015 S1474-4422(15)00044-7. - PMC - PubMed

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Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Affiliations

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

Authors

Affiliations

Abstract

References

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MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources