This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2016 Jun;61(6):1677-85.

doi: 10.1007/s10620-016-4041-5. Epub 2016 Feb 1.

Association Between Colorectal Cancer and Atherosclerotic Diseases: A Study Using a National Inpatient Database in Japan

Yutaka Yamaji¹, Hideo Yasunaga², Yoshihiro Hirata³, Atsuo Yamada³, Shuntaro Yoshida³, Hiromasa Horiguchi⁴, Kiyohide Fushimi⁵, Kazuhiko Koike³

Affiliations

Affiliations

¹ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. yamaji-tky@umin.ac.jp.
² Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
³ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
⁴ Department of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, 2-5-21 Higashigaoka, Meguro-ku, Tokyo, 152-8621, Japan.
⁵ Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

PMID: 26831490
DOI: 10.1007/s10620-016-4041-5

Association Between Colorectal Cancer and Atherosclerotic Diseases: A Study Using a National Inpatient Database in Japan

Yutaka Yamaji et al. Dig Dis Sci. 2016 Jun.

. 2016 Jun;61(6):1677-85.

doi: 10.1007/s10620-016-4041-5. Epub 2016 Feb 1.

Authors

Yutaka Yamaji¹, Hideo Yasunaga², Yoshihiro Hirata³, Atsuo Yamada³, Shuntaro Yoshida³, Hiromasa Horiguchi⁴, Kiyohide Fushimi⁵, Kazuhiko Koike³

Affiliations

¹ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. yamaji-tky@umin.ac.jp.
² Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
³ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
⁴ Department of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, 2-5-21 Higashigaoka, Meguro-ku, Tokyo, 152-8621, Japan.
⁵ Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

PMID: 26831490
DOI: 10.1007/s10620-016-4041-5

Abstract

Background: Both colorectal neoplasms and atherosclerosis can be induced by common visceral fat accumulation. However, the association between these diseases at the advanced stage, colorectal cancer and cardiovascular/cerebrovascular diseases, has not been elucidated.

Aims: This study aimed to investigate the association between colorectal cancer and vascular diseases in relation to obesity and metabolic disorders, using a nationwide database of hospitalized patients in Japan. We used non-cardiac gastric cancer patients as a reference, because they were considered to be neutral for obesity or metabolic disorders.

Methods: We identified 54,591 patients with colorectal cancer and 19,565 patients with gastric cancer from the Diagnosis Procedure Combination database. The data collected included: sex; age; body mass index (BMI); smoking status; comorbidity; and medication data, comprising hypertension, diabetes, hyperlipidemia, coronary artery disease, and stroke. We compared these data in a cross-sectional setting by multivariate analyses.

Results: Multivariate logistic regression analyses showed that female sex, increased BMI, hypertension [odds ratio (OR) 1.11; 95 % confidence interval (CI) 1.07-1.15; P < 0.0001], and diabetes (OR 1.17; 95 % CI 1.12-1.23; P < 0.0001) were more associated with colorectal cancer than with gastric cancer. Smoking, aspirin use (OR 0.85; 95 % CI 0.79-0.92; P < 0.0001), and coronary artery disease (OR 0.90; 95 % CI 0.86-0.95; P = 0.0001) were inversely associated with colorectal cancer.

Conclusions: Obesity and metabolic disorders were more associated with colorectal cancer than with non-cardiac gastric cancer, while coronary artery disease (CAD) was inversely associated. Some mechanisms involving separate populations of colorectal cancer and CAD under visceral fat accumulation might be suggested.

Keywords: Atherosclerosis; Colorectal neoplasms; Coronary disease; Obesity; Stroke.

PubMed Disclaimer

Similar articles

Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease.
Chan AO, Jim MH, Lam KF, Morris JS, Siu DC, Tong T, Ng FH, Wong SY, Hui WM, Chan CK, Lai KC, Cheung TK, Chan P, Wong G, Yuen MF, Lau YK, Lee S, Szeto ML, Wong BC, Lam SK. Chan AO, et al. JAMA. 2007 Sep 26;298(12):1412-9. doi: 10.1001/jama.298.12.1412. JAMA. 2007. PMID: 17895457
Association between colorectal adenoma and coronary atherosclerosis detected by CT coronary angiography in Korean men; a cross-sectional study.
Yang SY, Kim YS, Chung SJ, Song JH, Choi SY, Park MJ, Yim JY, Lim SH, Kim D, Kim CH, Kim JS, Song IS. Yang SY, et al. J Gastroenterol Hepatol. 2010 Nov;25(11):1795-9. doi: 10.1111/j.1440-1746.2010.06330.x. J Gastroenterol Hepatol. 2010. PMID: 21039843
Factors associated with colorectal cancer occurrence after colonoscopy that did not diagnose colorectal cancer.
Cheung D, Evison F, Patel P, Trudgill N. Cheung D, et al. Gastrointest Endosc. 2016 Aug;84(2):287-295.e1. doi: 10.1016/j.gie.2016.01.047. Epub 2016 Jan 28. Gastrointest Endosc. 2016. PMID: 26827612
Association Among Obesity, Metabolic Health, and the Risk for Colorectal Cancer in the General Population in Korea Using the National Health Insurance Service-National Sample Cohort.
Shin CM, Han K, Lee DH, Choi YJ, Kim N, Park YS, Yoon H. Shin CM, et al. Dis Colon Rectum. 2017 Nov;60(11):1192-1200. doi: 10.1097/DCR.0000000000000876. Dis Colon Rectum. 2017. PMID: 28991084
Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study.
Otani T, Iwasaki M, Yamamoto S, Sobue T, Hanaoka T, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group. Otani T, et al. Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1492-500. Cancer Epidemiol Biomarkers Prev. 2003. PMID: 14693743

See all similar articles

Cited by

Is emergency gastrointestinal system tumor surgery safe under treatment of antitrombotics?
İlhan M, Alizade E, Uzunyolcu G, Gök AFK, Gunay K, Ertekin C, Kurtoğlu M. İlhan M, et al. Ulus Travma Acil Cerrahi Derg. 2022 Jun;28(6):776-780. doi: 10.14744/tjtes.2022.92442. Ulus Travma Acil Cerrahi Derg. 2022. PMID: 35652882 Free PMC article.
Colorectal Cancer-The "Parent" of Low Bowel Obstruction.
Grigorean VT, Erchid A, Coman IS, Liţescu M. Grigorean VT, et al. Medicina (Kaunas). 2023 May 2;59(5):875. doi: 10.3390/medicina59050875. Medicina (Kaunas). 2023. PMID: 37241107 Free PMC article. Review.
Association between Colorectal Adenoma and Carotid Atherosclerosis in Korean Adults.
Kim H, Cho YJ, Kim YA, Gwak SG. Kim H, et al. Int J Environ Res Public Health. 2018 Dec 6;15(12):2762. doi: 10.3390/ijerph15122762. Int J Environ Res Public Health. 2018. PMID: 30563254 Free PMC article.

References

1. N Engl J Med. 2003 Apr 24;348(17):1625-38 - PubMed
1. Cancer. 2006 Jul 1;107(1):28-36 - PubMed
1. Cancer Epidemiol Biomarkers Prev. 2013 Aug;22(8):1395-408 - PubMed
1. Cancer Epidemiol Biomarkers Prev. 1998 Oct;7(10):869-73 - PubMed
1. Helicobacter. 2009 Apr;14(2):81-6 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal