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. 2016 Mar 1;26(5):1428-33.
doi: 10.1016/j.bmcl.2016.01.067. Epub 2016 Jan 22.

Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by Dictyostelium discoideum

Chihiro Murata  1 , Tetsuhiro Ogura  1 , Shuhei Narita  1 , Anna P Kondo  1 , Natsumi Iwasaki  1 , Tamao Saito  1 , Toyonobu Usuki  2
Affiliations

Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by Dictyostelium discoideum

Chihiro Murata et al. Bioorg Med Chem Lett. .

Abstract

4-Methyl-5-pentylbenzene-1,3-diol (MPBD) is a secondary metabolite of SteelyA polyketide synthase, which controls cell aggregation and spore maturation of Dictyostelium discoideum. In this study, chemical synthesis of MPBD and its derivatives was achieved. Structure-activity relationship (SAR) studies for antimicrobial activities against Escherichia coli and Bacillus subtilis were also conducted.

Keywords: 4-Methyl-5-pentylbenzene-1,3-diol; Antimicrobial activity; Dictyostelium discoideum; SAR study.

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