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. 2016 Mar 25;60(4):2551-3.
doi: 10.1128/AAC.02859-15. Print 2016 Apr.

The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri

Evgeny A Idelevich  1 , Frieder Schaumburg  1 , Dennis Knaack  1 , Anna S Scherzinger  2 , Wolfgang Mutter  2 , Georg Peters  1 , Andreas Peschel  3 , Karsten Becker  4
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The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri

Evgeny A Idelevich et al. Antimicrob Agents Chemother. .

Abstract

HY-133 is a recombinant bacteriophage endolysin with bactericidal activity againstStaphylococcus aureus Here, HY-133 showedin vitroactivity against major African methicillin-susceptible and methicillin-resistantS. aureuslineages and ceftaroline/ceftobiprole- and borderline oxacillin-resistant isolates. HY-133 was also active againstStaphylococcus schweitzeri, a recently described species of theS. aureuscomplex. The activity of HY-133 on the tested isolates (MIC50, 0.25 μg/ml; MIC90, 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.

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