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. 2016 Apr 22;60(5):3112-4.
doi: 10.1128/AAC.00007-16. Print 2016 May.

Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model

Cécile Vinot  1 , Jean-Marc Tréluyer  2 , Carole Giraud  3 , Laurent Gavard  4 , Gilles Peytavin  5 , Laurent Mandelbrot  6
Affiliations

Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model

Cécile Vinot et al. Antimicrob Agents Chemother. .

Abstract

Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.

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Figures

FIG 1
FIG 1
Fetal transfer rate (FTR) of RLT. Box plot of fetal transfer rate of RLT in the fetal-to-maternal (F-M) direction on the left (n = 6) and in the maternal-to-fetal (M-F) direction on the right (n = 3) (P = 0.07). Thick horizontal line indicates the mean, boxes indicate the interquartile range from 25th to 75th percentile, and whiskers indicate the maximum and minimum values.
FIG 2
FIG 2
Clearance index (CI) of RLT. Box plot of CI of RLT in the fetal-to-maternal (F-M) direction on the left (n = 6) and in the maternal-to-fetal (M-F) direction on the right (n = 3) (P = 0.63). Thick horizontal line indicates the mean, boxes indicate the interquartile range from 25th to 75th percentile, and whiskers indicate the maximum and minimum values.
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