New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

doi:10.1038/ncomms10495

Meta-Analysis

. 2016 Feb 1:7:10495.

doi: 10.1038/ncomms10495.

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu^{1

2}, Felix R Day³, Stefan Gustafsson^{4

5}, Martin L Buchkovich⁶, Jianbo Na⁷, Veronique Bataille^{8

9}, Diana L Cousminer¹⁰, Zari Dastani¹¹, Alexander W Drong¹², Tõnu Esko^{13

14

15

16}, David M Evans^{17

18}, Mario Falchi^{9

19}, Mary F Feitosa²⁰, Teresa Ferreira¹², Åsa K Hedman^{4

5

12}, Robin Haring^{21

22}, Pirro G Hysi⁹, Mark M Iles²³, Anne E Justice²⁴, Stavroula Kanoni^{25

26}, Vasiliki Lagou^{12

27}, Rui Li¹¹, Xin Li²⁸, Adam Locke²⁹, Chen Lu³⁰, Reedik Mägi^{12

13}, John R B Perry³, Tune H Pers^{15

16

31

32

33}, Qibin Qi³⁴, Marianna Sanna^{9

19}, Ellen M Schmidt³⁵, William R Scott^{36

37}, Dmitry Shungin^{38

39

40}, Alexander Teumer^{41

42}, Anna A E Vinkhuyzen⁴³, Ryan W Walker^{1

2}, Harm-Jan Westra^{44

45

46}, Mingfeng Zhang⁴⁷, Weihua Zhang^{36

37}, Jing Hua Zhao³, Zhihong Zhu⁴³, Uzma Afzal^{36

37}, Tarunveer Singh Ahluwalia^{31

48

49

50}, Stephan J L Bakker⁵¹, Claire Bellis⁵², Amélie Bonnefond^{53

54

55}, Katja Borodulin⁵⁶, Aron S Buchman⁵⁷, Tommy Cederholm⁵⁸, Audrey C Choh⁵⁹, Hyung Jin Choi⁶⁰, Joanne E Curran⁶¹, Lisette C P G M de Groot⁶², Philip L De Jager^{44

63

64}, Rosalie A M Dhonukshe-Rutten⁶², Anke W Enneman⁶⁵, Elodie Eury^{53

54

55}, Daniel S Evans⁶⁶, Tom Forsen⁶⁷, Nele Friedrich²¹, Frédéric Fumeron^{68

69

70

71}, Melissa E Garcia⁷², Simone Gärtner⁷³, Bok-Ghee Han⁷⁴, Aki S Havulinna⁵⁶, Caroline Hayward⁷⁵, Dena Hernandez⁷⁶, Hans Hillege⁷⁷, Till Ittermann⁴¹, Jack W Kent⁵², Ivana Kolcic⁷⁸, Tiina Laatikainen^{56

79

80}, Jari Lahti^{81

82}, Irene Mateo Leach⁷⁷, Christine G Lee^{83

84}, Jong-Young Lee⁷⁴, Tian Liu^{85

86}, Youfang Liu⁸⁷, Stéphane Lobbens^{53

54

55}, Marie Loh^{36

88}, Leo-Pekka Lyytikäinen^{89

90}, Carolina Medina-Gomez^{65

91

92}, Karl Michaëlsson⁹³, Mike A Nalls⁷⁶, Carrie M Nielson^{94

95}, Laticia Oozageer³⁷, Laura Pascoe⁹⁶, Lavinia Paternoster¹⁸, Ozren Polašek^{78

97}, Samuli Ripatti^{10

26

98}, Mark A Sarzynski⁹⁹, Chan Soo Shin¹⁰⁰, Nina Smolej Narančić¹⁰¹, Dominik Spira^{102

103}, Priya Srikanth^{94

95}, Elisabeth Steinhagen-Thiessen^{102

103}, Yun Ju Sung¹⁰⁴, Karin M A Swart^{105

106}, Leena Taittonen^{107

108}, Toshiko Tanaka¹⁰⁹, Emmi Tikkanen^{10

98}, Nathalie van der Velde⁶⁵, Natasja M van Schoor^{105

106}, Niek Verweij⁷⁷, Alan F Wright⁷⁵, Lei Yu⁵⁷, Joseph M Zmuda¹¹⁰, Niina Eklund⁵⁶, Terrence Forrester¹¹¹, Niels Grarup³¹, Anne U Jackson²⁹, Kati Kristiansson^{10

56}, Teemu Kuulasmaa¹¹², Johanna Kuusisto^{112

113

114}, Peter Lichtner¹¹⁵, Jian'an Luan³, Anubha Mahajan¹², Satu Männistö⁵⁶, Cameron D Palmer^{14

15}, Janina S Ried¹¹⁶, Robert A Scott³, Alena Stancáková¹¹⁷, Peter J Wagner^{10

56}, Ayse Demirkan¹¹⁸, Angela Döring^{119

120}, Vilmundur Gudnason^{121

122}, Douglas P Kiel^{123

124}, Brigitte Kühnel^{116

120

125}, Massimo Mangino⁹, Barbara Mcknight^{126

127

128}, Cristina Menni⁹, Jeffrey R O'Connell¹²⁹, Ben A Oostra¹¹⁸, Alan R Shuldiner^{129

130}, Kijoung Song¹³¹, Liesbeth Vandenput¹³², Cornelia M van Duijn^{91

118

133}, Peter Vollenweider¹³⁴, Charles C White³⁰, Michael Boehnke²⁹, Yvonne Boettcher^{135

136}, Richard S Cooper¹³⁷, Nita G Forouhi³, Christian Gieger^{116

120

125}, Harald Grallert^{120

125

138}, Aroon Hingorani¹³⁹, Torben Jørgensen^{140

141

142}, Pekka Jousilahti⁵⁶, Mika Kivimaki¹⁴³, Meena Kumari¹⁴³, Markku Laakso^{112

113

114}, Claudia Langenberg^{3

143}, Allan Linneberg¹⁴⁴, Amy Luke¹³⁷, Colin A Mckenzie¹¹¹, Aarno Palotie^{10

26

145}, Oluf Pedersen³¹, Annette Peters^{120

125}, Konstantin Strauch^{116

146}, Bamidele O Tayo¹³⁷, Nicholas J Wareham³, David A Bennett⁵⁷, Lars Bertram^{147

148}, John Blangero⁶¹, Matthias Blüher^{135

136}, Claude Bouchard⁹⁹, Harry Campbell⁹⁷, Nam H Cho¹⁴⁹, Steven R Cummings⁶⁶, Stefan A Czerwinski⁵⁹, Ilja Demuth^{102

150}, Rahel Eckardt¹⁰², Johan G Eriksson^{56

67

81}, Luigi Ferrucci¹⁰⁹, Oscar H Franco^{91

92}, Philippe Froguel^{53

54

55}, Ron T Gansevoort⁵¹, Torben Hansen^{31

151}, Tamara B Harris⁷², Nicholas Hastie⁷⁵, Markku Heliövaara⁵⁶, Albert Hofman^{91

92}, Joanne M Jordan⁸⁷, Antti Jula⁵⁶, Mika Kähönen^{152

153}, Eero Kajantie^{56

154

155}, Paul B Knekt⁵⁶, Seppo Koskinen⁵⁶, Peter Kovacs¹³⁵, Terho Lehtimäki^{89

90}, Lars Lind¹⁵⁶, Yongmei Liu¹⁵⁷, Eric S Orwoll⁹⁵, Clive Osmond¹⁵⁸, Markus Perola^{10

13

56}, Louis Pérusse^{159

160}, Olli T Raitakari^{161

162}, Tuomo Rankinen⁹⁹, D C Rao^{20

104

163}, Treva K Rice^{104

163}, Fernando Rivadeneira^{65

91

92}, Igor Rudan⁹⁷, Veikko Salomaa⁵⁶, Thorkild I A Sørensen^{18

31

164}, Michael Stumvoll^{135

136}, Anke Tönjes¹³⁶, Bradford Towne⁵⁹, Gregory J Tranah⁶⁶, Angelo Tremblay¹⁵⁹, André G Uitterlinden^{65

91

92}, Pim van der Harst^{77

165

166}, Erkki Vartiainen⁵⁶, Jorma S Viikari¹⁶⁷, Veronique Vitart⁷⁵, Marie-Claude Vohl^{160

168}, Henry Völzke^{41

169

170}, Mark Walker^{44

171}, Henri Wallaschofski^{21

169}, Sarah Wild¹⁷², James F Wilson^{75

97}, Loïc Yengo^{53

54

55}, D Timothy Bishop²³, Ingrid B Borecki^{20

173}, John C Chambers^{36

37

174}, L Adrienne Cupples^{30

175}, Abbas Dehghan¹⁷⁶, Panos Deloukas^{25

26

177}, Ghazaleh Fatemifar¹⁸, Caroline Fox^{63

175}, Terrence S Furey^{6

178}, Lude Franke^{77

166}, Jiali Han¹⁷⁹, David J Hunter^{14

28

180

181}, Juha Karjalainen¹⁶⁶, Fredrik Karpe^{27

182}, Robert C Kaplan³⁴, Jaspal S Kooner^{37

174

183}, Mark I McCarthy^{12

27

182}, Joanne M Murabito^{184

185}, Andrew P Morris^{12

186}, Julia A N Bishop²³, Kari E North¹⁸⁷, Claes Ohlsson¹³², Ken K Ong^{3

188

189}, Inga Prokopenko^{12

19

27}, J Brent Richards^{11

190

191

192}, Eric E Schadt^{193

194}, Tim D Spector⁹, Elisabeth Widén¹⁰, Cristen J Willer^{35

195

196}, Jian Yang⁴³, Erik Ingelsson^{4

5

197}, Karen L Mohlke⁶, Joel N Hirschhorn^{14

15

16}, John Andrew Pospisilik¹⁹⁸, M Carola Zillikens^{65

91}, Cecilia Lindgren^{12

14

199}, Tuomas Oskari Kilpeläinen^{3

31}, Ruth J F Loos^{1

2

3

200

201}

Affiliations

¹ The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
² The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
³ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
⁴ Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.
⁵ Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden.
⁶ Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
⁷ Department of Developmental and Regenerative Biology, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
⁸ West Herts NHS Trust, Herts HP2 4AD, UK.
⁹ Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
¹⁰ Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
¹¹ Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
¹² Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
¹³ Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.
¹⁴ Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
¹⁵ Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
¹⁶ Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
¹⁷ University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
¹⁸ MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
¹⁹ Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.
²⁰ Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
²¹ Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
²² European University of Applied Sciences, Faculty of Applied Public Health, 18055 Rostock, Germany.
²³ Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
²⁴ Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
²⁵ William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
²⁶ Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
²⁷ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
²⁸ Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
²⁹ Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
³⁰ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
³¹ Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
³² Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge 02142, USA.
³³ Department of Epidemiology Research, Statens Serum Institut, 2100 Copenhagen, Denmark.
³⁴ Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
³⁵ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
³⁶ Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
³⁷ Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
³⁸ Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden.
³⁹ Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.
⁴⁰ Department of Odontology, Umeå University, 901 85 Umeå, Sweden.
⁴¹ Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
⁴² Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
⁴³ Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
⁴⁴ Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
⁴⁵ Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02446, USA.
⁴⁶ Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02446, USA.
⁴⁷ Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
⁴⁸ Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sceinces, University of Copenhagen, 2200 Copenhagen, Denmark.
⁴⁹ Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, 2200 Copenhagen, Denmark.
⁵⁰ Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.
⁵¹ University of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands.
⁵² Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA.
⁵³ CNRS UMR 8199, F-59019 Lille, France.
⁵⁴ European Genomic Institute for Diabetes, 59000 Lille, France.
⁵⁵ Université de Lille 2, 59000 Lille, France.
⁵⁶ National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
⁵⁷ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
⁵⁸ Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 85 Uppsala, Sweden.
⁵⁹ Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
⁶⁰ Department of Anatomy, Seoul National University College of Medicine, Seoul 03080, Korea.
⁶¹ South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520.
⁶² Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
⁶³ Harvard Medical School, Boston, Massachusetts 02115, USA.
⁶⁴ Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
⁶⁵ Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
⁶⁶ California Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
⁶⁷ Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.
⁶⁸ INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁶⁹ Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁷⁰ Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁷¹ Univ Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁷² Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA.
⁷³ Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany.
⁷⁴ Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea.
⁷⁵ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
⁷⁶ Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
⁷⁷ University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
⁷⁸ Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
⁷⁹ Hospital District of North Karelia, FI-80210 Joensuu, Finland.
⁸⁰ Institute of Public Health and Clinical Nutrition, University of Eastern Finland, FI-70211 Kuopio, Finland.
⁸¹ Folkhälsan Research Centre, FI-00290 Helsinki, Finland.
⁸² Institute of Behavioural Sciences, University of Helsinki, FI-00014 Helsinki, Finland.
⁸³ Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
⁸⁴ Research Service, Veterans Affairs Medical Center, Portland, Oregon 97239, USA.
⁸⁵ Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany.
⁸⁶ Max Planck Institute for Human Development, 14194 Berlin, Germany.
⁸⁷ Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA.
⁸⁸ Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648, Singapore.
⁸⁹ Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
⁹⁰ Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland.
⁹¹ Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
⁹² Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
⁹³ Department of Surgical Sciences, Orthopedics, Uppsala University, 751 85 Uppsala, Sweden.
⁹⁴ School of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.
⁹⁵ Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.
⁹⁶ Institute of Cell &Molecular Biosciences, Newcastle University, Newcastle NE1 7RU, UK.
⁹⁷ Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
⁹⁸ Hjelt Institute, University of Helsinki, FI-00014 Helsinki, Finland.
⁹⁹ Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
¹⁰⁰ Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
¹⁰¹ Institute for Anthropological Research, Zagreb 10000, Croatia.
¹⁰² The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
¹⁰³ Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
¹⁰⁴ Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
¹⁰⁵ EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
¹⁰⁶ VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands.
¹⁰⁷ Department of Pediatrics, University of Oulu, FI-90014 Oulu, Finland.
¹⁰⁸ Department of Pediatrics, Vaasa Central Hospital, FI-65100 Vaasa, Finland.
¹⁰⁹ Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
¹¹⁰ Department of Epidemiology; University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
¹¹¹ Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
¹¹² Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
¹¹³ Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
¹¹⁴ Kuopio University Hospital, 70029 Kuopio, Finland.
¹¹⁵ Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹¹⁶ Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹¹⁷ Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
¹¹⁸ Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
¹¹⁹ Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹²⁰ Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹²¹ Icelandic Heart Association, Kopavogur 201, Iceland.
¹²² University of Iceland, Faculty of Medicine, Reykjavik 101, Iceland.
¹²³ Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.
¹²⁴ Institute for Aging Research Hebrew Senior Life, Boston, Massachusetts 02131, USA.
¹²⁵ Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹²⁶ Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
¹²⁷ Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
¹²⁸ Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
¹²⁹ Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
¹³⁰ Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA.
¹³¹ Genetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline, Philadelphia, Pennsylvania 19112, USA.
¹³² Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
¹³³ Center for Medical Systems Biology, 2300 Leiden, The Netherlands.
¹³⁴ Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
¹³⁵ University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
¹³⁶ University of Leipzig, Department of Medicine, 04103 Leipzig, Germany.
¹³⁷ Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
¹³⁸ German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
¹³⁹ Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
¹⁴⁰ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
¹⁴¹ Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.
¹⁴² Research Centre for Prevention and Health, DK2600 Capital Region of Denmark, Denmark.
¹⁴³ Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
¹⁴⁴ Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
¹⁴⁵ Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA.
¹⁴⁶ Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
¹⁴⁷ School of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
¹⁴⁸ Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, 23562 Lübeck, Germany.
¹⁴⁹ Ajou University School of Medicine, Department of Preventive Medicine, Suwon Kyoung-gi 443-721, Korea.
¹⁵⁰ Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
¹⁵¹ Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
¹⁵² Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.
¹⁵³ Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
¹⁵⁴ Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.
¹⁵⁵ Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland.
¹⁵⁶ Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
¹⁵⁷ Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
¹⁵⁸ MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
¹⁵⁹ Department of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.
¹⁶⁰ Institute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6.
¹⁶¹ Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
¹⁶² Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland.
¹⁶³ Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
¹⁶⁴ Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, 2000 Frederiksberg, Denmark.
¹⁶⁵ Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.
¹⁶⁶ Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
¹⁶⁷ Department of Medicine, University of Turku, FI-20521 Turku, Finland.
¹⁶⁸ School of Nutrition, Laval University, Québec City, Quebec, Canada G1V 0A6.
¹⁶⁹ DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.
¹⁷⁰ DZD (German Centre for Diabetes Research), partner site Greifswald, 17475 Greifswald, Germany.
¹⁷¹ Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.
¹⁷² Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
¹⁷³ Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
¹⁷⁴ Imperial College Healthcare NHS Trust, London W12 0HS, UK.
¹⁷⁵ National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
¹⁷⁶ Department of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands.
¹⁷⁷ Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
¹⁷⁸ Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
¹⁷⁹ Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
¹⁸⁰ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
¹⁸¹ Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
¹⁸² Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK.
¹⁸³ National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
¹⁸⁴ Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.
¹⁸⁵ NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
¹⁸⁶ Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
¹⁸⁷ Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
¹⁸⁸ MRC Unit for Lifelong Health and Ageing at UCL, London WC1B 5JU, UK.
¹⁸⁹ Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
¹⁹⁰ Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
¹⁹¹ Department of Twin Research, King's College London, London SE1 1E7, UK.
¹⁹² Division of Endocrinology, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
¹⁹³ Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
¹⁹⁴ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
¹⁹⁵ Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
¹⁹⁶ Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
¹⁹⁷ Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
¹⁹⁸ Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, D-76108 Freiburg, Germany.
¹⁹⁹ The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK.
²⁰⁰ The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
²⁰¹ The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

PMID: 26833246
PMCID: PMC4740398
DOI: 10.1038/ncomms10495

Meta-Analysis

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu et al. Nat Commun. 2016.

. 2016 Feb 1:7:10495.

doi: 10.1038/ncomms10495.

Authors

Affiliations

¹ The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
² The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
³ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
⁴ Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.
⁵ Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden.
⁶ Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
⁷ Department of Developmental and Regenerative Biology, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
⁸ West Herts NHS Trust, Herts HP2 4AD, UK.
⁹ Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
¹⁰ Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
¹¹ Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
¹² Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
¹³ Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.
¹⁴ Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
¹⁵ Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
¹⁶ Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
¹⁷ University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
¹⁸ MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
¹⁹ Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.
²⁰ Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
²¹ Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
²² European University of Applied Sciences, Faculty of Applied Public Health, 18055 Rostock, Germany.
²³ Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
²⁴ Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
²⁵ William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
²⁶ Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
²⁷ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
²⁸ Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
²⁹ Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
³⁰ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
³¹ Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
³² Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge 02142, USA.
³³ Department of Epidemiology Research, Statens Serum Institut, 2100 Copenhagen, Denmark.
³⁴ Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
³⁵ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
³⁶ Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
³⁷ Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
³⁸ Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden.
³⁹ Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.
⁴⁰ Department of Odontology, Umeå University, 901 85 Umeå, Sweden.
⁴¹ Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
⁴² Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
⁴³ Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
⁴⁴ Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
⁴⁵ Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02446, USA.
⁴⁶ Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02446, USA.
⁴⁷ Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
⁴⁸ Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sceinces, University of Copenhagen, 2200 Copenhagen, Denmark.
⁴⁹ Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, 2200 Copenhagen, Denmark.
⁵⁰ Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.
⁵¹ University of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands.
⁵² Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA.
⁵³ CNRS UMR 8199, F-59019 Lille, France.
⁵⁴ European Genomic Institute for Diabetes, 59000 Lille, France.
⁵⁵ Université de Lille 2, 59000 Lille, France.
⁵⁶ National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
⁵⁷ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
⁵⁸ Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 85 Uppsala, Sweden.
⁵⁹ Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
⁶⁰ Department of Anatomy, Seoul National University College of Medicine, Seoul 03080, Korea.
⁶¹ South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520.
⁶² Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
⁶³ Harvard Medical School, Boston, Massachusetts 02115, USA.
⁶⁴ Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
⁶⁵ Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
⁶⁶ California Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
⁶⁷ Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.
⁶⁸ INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁶⁹ Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁷⁰ Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁷¹ Univ Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
⁷² Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA.
⁷³ Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany.
⁷⁴ Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea.
⁷⁵ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
⁷⁶ Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
⁷⁷ University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
⁷⁸ Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
⁷⁹ Hospital District of North Karelia, FI-80210 Joensuu, Finland.
⁸⁰ Institute of Public Health and Clinical Nutrition, University of Eastern Finland, FI-70211 Kuopio, Finland.
⁸¹ Folkhälsan Research Centre, FI-00290 Helsinki, Finland.
⁸² Institute of Behavioural Sciences, University of Helsinki, FI-00014 Helsinki, Finland.
⁸³ Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
⁸⁴ Research Service, Veterans Affairs Medical Center, Portland, Oregon 97239, USA.
⁸⁵ Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany.
⁸⁶ Max Planck Institute for Human Development, 14194 Berlin, Germany.
⁸⁷ Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA.
⁸⁸ Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648, Singapore.
⁸⁹ Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
⁹⁰ Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland.
⁹¹ Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
⁹² Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
⁹³ Department of Surgical Sciences, Orthopedics, Uppsala University, 751 85 Uppsala, Sweden.
⁹⁴ School of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.
⁹⁵ Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.
⁹⁶ Institute of Cell &Molecular Biosciences, Newcastle University, Newcastle NE1 7RU, UK.
⁹⁷ Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
⁹⁸ Hjelt Institute, University of Helsinki, FI-00014 Helsinki, Finland.
⁹⁹ Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
¹⁰⁰ Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
¹⁰¹ Institute for Anthropological Research, Zagreb 10000, Croatia.
¹⁰² The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
¹⁰³ Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
¹⁰⁴ Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
¹⁰⁵ EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
¹⁰⁶ VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands.
¹⁰⁷ Department of Pediatrics, University of Oulu, FI-90014 Oulu, Finland.
¹⁰⁸ Department of Pediatrics, Vaasa Central Hospital, FI-65100 Vaasa, Finland.
¹⁰⁹ Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
¹¹⁰ Department of Epidemiology; University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
¹¹¹ Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
¹¹² Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
¹¹³ Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
¹¹⁴ Kuopio University Hospital, 70029 Kuopio, Finland.
¹¹⁵ Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹¹⁶ Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹¹⁷ Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
¹¹⁸ Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
¹¹⁹ Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹²⁰ Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹²¹ Icelandic Heart Association, Kopavogur 201, Iceland.
¹²² University of Iceland, Faculty of Medicine, Reykjavik 101, Iceland.
¹²³ Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.
¹²⁴ Institute for Aging Research Hebrew Senior Life, Boston, Massachusetts 02131, USA.
¹²⁵ Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
¹²⁶ Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
¹²⁷ Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
¹²⁸ Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
¹²⁹ Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
¹³⁰ Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA.
¹³¹ Genetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline, Philadelphia, Pennsylvania 19112, USA.
¹³² Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
¹³³ Center for Medical Systems Biology, 2300 Leiden, The Netherlands.
¹³⁴ Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
¹³⁵ University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
¹³⁶ University of Leipzig, Department of Medicine, 04103 Leipzig, Germany.
¹³⁷ Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
¹³⁸ German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
¹³⁹ Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
¹⁴⁰ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
¹⁴¹ Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.
¹⁴² Research Centre for Prevention and Health, DK2600 Capital Region of Denmark, Denmark.
¹⁴³ Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
¹⁴⁴ Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
¹⁴⁵ Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA.
¹⁴⁶ Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
¹⁴⁷ School of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
¹⁴⁸ Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, 23562 Lübeck, Germany.
¹⁴⁹ Ajou University School of Medicine, Department of Preventive Medicine, Suwon Kyoung-gi 443-721, Korea.
¹⁵⁰ Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
¹⁵¹ Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
¹⁵² Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.
¹⁵³ Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
¹⁵⁴ Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.
¹⁵⁵ Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland.
¹⁵⁶ Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
¹⁵⁷ Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
¹⁵⁸ MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
¹⁵⁹ Department of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.
¹⁶⁰ Institute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6.
¹⁶¹ Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
¹⁶² Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland.
¹⁶³ Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
¹⁶⁴ Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, 2000 Frederiksberg, Denmark.
¹⁶⁵ Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.
¹⁶⁶ Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
¹⁶⁷ Department of Medicine, University of Turku, FI-20521 Turku, Finland.
¹⁶⁸ School of Nutrition, Laval University, Québec City, Quebec, Canada G1V 0A6.
¹⁶⁹ DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.
¹⁷⁰ DZD (German Centre for Diabetes Research), partner site Greifswald, 17475 Greifswald, Germany.
¹⁷¹ Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.
¹⁷² Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
¹⁷³ Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
¹⁷⁴ Imperial College Healthcare NHS Trust, London W12 0HS, UK.
¹⁷⁵ National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
¹⁷⁶ Department of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands.
¹⁷⁷ Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
¹⁷⁸ Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
¹⁷⁹ Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
¹⁸⁰ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
¹⁸¹ Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
¹⁸² Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK.
¹⁸³ National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
¹⁸⁴ Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.
¹⁸⁵ NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
¹⁸⁶ Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
¹⁸⁷ Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
¹⁸⁸ MRC Unit for Lifelong Health and Ageing at UCL, London WC1B 5JU, UK.
¹⁸⁹ Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
¹⁹⁰ Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
¹⁹¹ Department of Twin Research, King's College London, London SE1 1E7, UK.
¹⁹² Division of Endocrinology, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
¹⁹³ Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
¹⁹⁴ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
¹⁹⁵ Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
¹⁹⁶ Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
¹⁹⁷ Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
¹⁹⁸ Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, D-76108 Freiburg, Germany.
¹⁹⁹ The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK.
²⁰⁰ The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
²⁰¹ The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

PMID: 26833246
PMCID: PMC4740398
DOI: 10.1038/ncomms10495

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

PubMed Disclaimer

Conflict of interest statement

R.E. received honoraria for lectures from the following companies (within the past 2 years): MSD Sharp&Dohme and Pfizer. J.M.J. disclosed Trinity Partners, Inc., Osteoarthritis Research Society International, Chronic Osteoarthritis Management Initiative of US Bone and Joint Initiative, Samumed, Interleukin Genetics, Inc. and Algynomics, Inc. K.S. is a full-time employee of GlaxoSmithKline. D.S. received honoraria for lectures from the following companies (within the past 2 years): MSD Sharp&Dohme. E.S.-T. received honoraria for lectures, research grants and consultancy fees from the following companies (within the past 2 years): Aegerion, Fresenius, MSD Sharp&Dohme, Pfizer and Sanofi. Peter Vollenweider received an unrestricted grant from GSK to build the CoLaus study.

Figures

**Figure 1. Regional plots of the four newly identified loci that reached genome-wide significant association with body fat percentage.**
Regional plots of the four newly identified loci that reached genome-wide significant association with body fat percentage in all-ancestry analyses, in men and women combined for the *COBLL1/GRB14* and *IGF2BP1* loci (a,b), and separately for the *CRTC1* and *PLA2G6* (c,d). Each symbol represents the significance (P value on a −log10 scale) of a SNP with BF% as a function of the SNP's genomic position (NCBI Build 36). For each locus, the index SNP is represented in the purple colour. The colour of all other SNPs indicates LD with the index SNP (estimated by CEU r² from the HapMap Project data Phase II CEU). Recombination rates are also estimated from International HapMap Project data, and gene annotations are obtained from the UCSC Genome Browser. GWAS catalogues SNPs with P value <5 × 10⁻⁸ are shown in the middle panel. Different shapes denote the different categories of the SNPs: up-triangle for framestop or splice SNPs, down-triangle for nonsynonymous SNPs, square for coding or untranslated region (UTR) SNPs; star for SNPs in tfbscons region, square filled with ‘X' symbol for SNPs located in mcs44placental region and circle for SNPs with no annotation information.

**Figure 2. Comparison of effects of the 12 loci on body fat percentage (x axis) and on BMI (y axis).**
Both outcomes (BMI and BF%) were inverse normally transformed (mean 0, s.d. 1) such that effects sizes are at the same scales and directly comparable. Effect sizes for BMI were obtained from Locke *et al.*. The allele effects for the *PLA2G6* (square) and *CRTC1* (round) loci were derived, respectively, from the men- and women-based meta-analyses. Six loci had first been identified for BMI (blue), whereas six others were first identified for BF% (green).

**Figure 3. Genotype influences Pol2 binding at rs4808844.**
(a) UCSC Genome browser track (hg19) of chromosome 16 displaying Pol2 binding signal in 10 lymphoblastoid cell lines (LCLs), grouped by genotype and correlations between DNaseI hypersensitivity and nearby gene transcription. (b) Binding signals from Pol2 ChIP-seq from 10 LCLs, grouped by genotype.

See this image and copyright information in PMC

Cited by

Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study.
Li CL, Liu YK, Lan YY, Wang ZS. Li CL, et al. World J Clin Cases. 2024 Jul 16;12(20):4272-4288. doi: 10.12998/wjcc.v12.i20.4272. World J Clin Cases. 2024. PMID: 39015929 Free PMC article.
Genetic variants in SEC16B are associated with body composition in black South Africans.
Sahibdeen V, Crowther NJ, Soodyall H, Hendry LM, Munthali RJ, Hazelhurst S, Choudhury A, Norris SA, Ramsay M, Lombard Z. Sahibdeen V, et al. Nutr Diabetes. 2018 Jul 19;8(1):43. doi: 10.1038/s41387-018-0050-0. Nutr Diabetes. 2018. PMID: 30026463 Free PMC article.
Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients.
Delacrétaz A, Glatard A, Dubath C, Gholam-Rezaee M, Sanchez-Mut JV, Gräff J, von Gunten A, Conus P, Eap CB. Delacrétaz A, et al. Clin Epigenetics. 2019 Dec 26;11(1):198. doi: 10.1186/s13148-019-0792-0. Clin Epigenetics. 2019. PMID: 31878957 Free PMC article.
Editorial: Novel Biomarkers for Type 2 Diabetes.
Ahluwalia TS, Kilpeläinen TO, Singh S, Rossing P. Ahluwalia TS, et al. Front Endocrinol (Lausanne). 2019 Sep 27;10:649. doi: 10.3389/fendo.2019.00649. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31611845 Free PMC article. No abstract available.
Causes of obesity: a review.
Masood B, Moorthy M. Masood B, et al. Clin Med (Lond). 2023 Jul;23(4):284-291. doi: 10.7861/clinmed.2023-0168. Clin Med (Lond). 2023. PMID: 37524429 Free PMC article. Review.

See all "Cited by" articles

References

1. Frayling T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894 (2007). - PMC - PubMed
1. Scuteri A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007). - PMC - PubMed
1. Loos R. J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768–775 (2008). - PMC - PubMed
1. Chambers J. C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716–718 (2008). - PubMed
1. Willer C. J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34 (2009). - PMC - PubMed

Publication types

Actions
Actions
Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information
- The YODA Project
Molecular Biology Databases
- FlyBase
Miscellaneous
- NCI CPTAC Assay Portal

[1] Frayling T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894 (2007). - PMC - PubMed

[2] Frayling T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894 (2007). - PMC - PubMed

[3] Scuteri A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007). - PMC - PubMed

[4] Scuteri A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007). - PMC - PubMed

[5] Loos R. J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768–775 (2008). - PMC - PubMed

[6] Loos R. J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768–775 (2008). - PMC - PubMed

[7] Chambers J. C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716–718 (2008). - PubMed

[8] Chambers J. C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716–718 (2008). - PubMed

[9] Willer C. J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34 (2009). - PMC - PubMed

[10] Willer C. J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34 (2009). - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Affiliations

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Miscellaneous

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Miscellaneous