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. 2016 Feb;10(1):23-30.
doi: 10.1007/s11571-015-9361-1. Epub 2015 Nov 4.

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

Yingshou Xing  1 , Yi Qin  2 , Wei Jing  2 , Yunxiang Zhang  2 , Yanran Wang  2 , Daqing Guo  3 , Yang Xia  3 , Dezhong Yao  3
Affiliations

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

Yingshou Xing et al. Cogn Neurodyn. 2016 Feb.

Abstract

Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.

Keywords: Cognitive damage; Morris water maze; Mozart music; Status epilepticus.

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Figures

Fig. 1
Fig. 1
Morris water maze performance in the control and epilepsy groups. a Escape latency for control rats compared with epilepsy group rats. b Time in quadrants for control rats compared with epilepsy group rats. Data is presented mean ± SEM. Single asterisk represents statistical differences at P < 0.05 and double asterisk represents statistical differences at P < 0.01. SED10: from 10 to 14 days after SE; SED20: from 20 to 24 days after SE; SED30: from 30 to 34 days after SE. Control group n = 10; Epilepsy group n = 10
Fig. 2
Fig. 2
Morris water maze performance in the Mozart-epilepsy and epilepsy groups. a Escape latency for Mozart-epilepsy group compared with epilepsy group. b Time in quadrants for Mozart-epilepsy group compared with epilepsy group. Data is presented mean ± SEM. Single asterisk represents statistical differences at P < 0.05 and double asterisk represents statistical differences at P < 0.01. SED10: from 10 to 14 days after SE; SED20: from 20 to 24 days after SE; SED30: from 30 to 34 days after SE. Epilepsy group n = 10; Mozart-epilepsy group n = 10
Fig. 3
Fig. 3
Comparison of the learning rates among the different groups. Three groups are: Epilepsy group (a), Mozart-epilepsy group (b) and Control group (c). d The slope values for Mozart-epilepsy group compared with epilepsy group. Single asterisk represents P < 0.05. Control group n = 10; Epilepsy group n = 10; Mozart-epilepsy group n = 10
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References

    1. Aldenkamp A, Arends J. The relative influence of epileptic EEG discharges, short nonconvulsive seizures, and type of epilepsy on cognitive function. Epilepsia. 2004;45:54–63. doi: 10.1111/j.0013-9580.2004.33403.x. - DOI - PubMed
    1. Aoun P, Jones T, Shaw GL, Bodner M. Long-term enhancement of maze learning in mice via a generalized Mozart effect. Neurol Res. 2005;27:791–796. doi: 10.1179/016164105X63647. - DOI - PubMed
    1. Bodner M, Muftuler LT, Nalcioglu O, et al. FMRI study relevant to the Mozart effect: brain areas involved in spatial-temporal reasoning. Neurol Res. 2001;23:683–690. doi: 10.1179/016164101101199108. - DOI - PubMed
    1. Bridgett DJ, Cuevas J. Effects of listening to Mozart and Bach on the performance of a mathematical test. Percept Mot Skills. 2000;90(3):1171–1175. doi: 10.2466/pms.2000.90.3c.1171. - DOI - PubMed
    1. Brown SR. Emergence in the central nervous system. Cogn Neurodyn. 2013;7(3):173–195. doi: 10.1007/s11571-012-9229-6. - DOI - PMC - PubMed