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Case Reports
. 2015 Nov 12;3(4):128-31.
doi: 10.1002/rcr2.135. eCollection 2015 Dec.

Organizing pneumonia associated with M ycobacterium tuberculosis infection

Hyung Seok Yoon  1 , Eun Joo Lee  1 , Jung Yeon Lee  1 , Gyu Rak Chon  1 , Sang Ho Lee  2 , Se Jin Kim  3
Affiliations
Case Reports

Organizing pneumonia associated with M ycobacterium tuberculosis infection

Hyung Seok Yoon et al. Respirol Case Rep. .

Abstract

Organizing pneumonia is an inflammatory lung disease involving the distal bronchioles, respiratory bronchioles, bronchiolar ducts, and alveoli. A number of viral and bacterial organisms have been identified as causative agents of organizing pneumonia. However, M ycobacterium tuberculosis has rarely been reported as a causative agent. Herein, we report our experience with two patients diagnosed with pulmonary tuberculosis, whose biopsies showed patterns associated with organizing pneumonia. Both patients showed positive results for bacteriological tests and presence of acid fast bacilli. Hence, we could successfully treat both patients with anti-tuberculosis medications. Our report suggests that M . tuberculosis infection could be added to the list of infectious conditions associated with organizing pneumonia.

Keywords: Organizing pneumonia; pathology; tuberculosis.

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Figures

Figure 1
Figure 1
In case 1, (A) chest radiography showed multifocal consolidation in the right upper, right lower, and left lower lung fields on admission. (B) High‐resolution computed tomography showed multifocal consolidation in the right upper, right lower, and left lower lobe with small nodules. (C) Percutaneous needle aspiration lung biopsy revealed interstitial fibroblast infiltrations with collagen depositions and multiple foci of fibroblastic plug, obstructing air spaces (hematoxylin and eosin stain ×100). (D) Follow‐up chest radiography after a 2‐month steroid treatment showed a decreased extent of patch consolidation in both lung fields.
Figure 2
Figure 2
In case 2, (A) chest radiography demonstrated multifocal consolidation with an air bronchogram in the right upper lung field on admission. (B) High‐resolution computed tomography revealed multifocal consolidation with air bronchogram and ground‐glass opacities in the posterior segment of the right upper lobe on admission. (C) Transbronchial lung biopsy revealed a few interstitial fibroblastic infiltrations with interstitial thickening and several intra‐alveolar fibrinoid materials (hematoxylin and eosin stain ×100). (D) Follow‐up chest radiography after 2‐month anti‐tuberculosis treatments showed a decrease of patch consolidation in the right lung field.
See this image and copyright information in PMC

References

    1. Al‐Ghanem S, Al‐Jahdali H, Bamefleh H, et al. 2008. Bronchiolitis obliterans organizing pneumonia: Pathogenesis, clinical features, imaging and therapy review. Ann. Thorac. Med. 3:67–75. - PMC - PubMed
    1. Fullmer JJ, Fan LL, Dishop MK, et al. 2005. Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor‐alpha blockade. Pediatrics 116:767–770. - PubMed
    1. Cordier JF. 2000. Organising pneumonia. Thorax 55:318–328. - PMC - PubMed
    1. Hsieh MH, and Lin CY. 2014. Pulmonary tuberculosis presenting as organizing pneumonia. Am. J. Respir. Crit. Care Med. 189:e63. - PubMed
    1. Kim YC, Jang AS, Kim JS, et al. 2002. A case of pulmonary tuberculosis following bronchiolitis obliterans with organizing pneumonia (BOOP). Chonnam Med. J. 38:170–174.

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