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. 2016 Jan 20:5:55.
doi: 10.1186/s40064-016-1703-x. eCollection 2016.

New building blocks or dendritic pseudopeptides for metal chelating

Min Ruan  1 , Irène Nicolas  1 , Michèle Baudy-Floc'h  1
Affiliations

New building blocks or dendritic pseudopeptides for metal chelating

Min Ruan et al. Springerplus. .

Abstract

Dendritic oligopeptides have been reported as useful building blocks for many interactions. Starting from hydrazine, we described an approach to create new dendritic pseudopeptides linked with biological systems, such as cell membrane, as chelate metal, Ni(2+)-nitrilotriacetic acid moieties which could target histidine rich peptides or proteins. Depending on the nature of these new chemical recognition units, they could be integrated into a peptide by coupling in C or N-termini.Graphical abstract:Dendrimer formation.

Keywords: Aza-NTA; Aza-β3-amino acids; Aza-β3-peptides; Dendritic pseudopeptides.

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Figures

Graphical abstract:
Graphical abstract:
Dendrimer formation
Scheme 1
Scheme 1
Synthesis of aza-NTA 6
Scheme 2
Scheme 2
Synthesis of aza-NTA 12
Scheme 3
Scheme 3
Synthesis of aza-NTA 19
Scheme 4
Scheme 4
Synthesis of multimeric aza-NTA or dendritic pseudopeptides
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