Review
doi: 10.1093/ageing/18.4.223.
Clinical experience with and side-effects of tacrine hydrochloride in Alzheimer's disease: a pilot study
Affiliations
- PMID: 2683619
- DOI: 10.1093/ageing/18.4.223
Item in Clipboard
Review
Clinical experience with and side-effects of tacrine hydrochloride in Alzheimer's disease: a pilot study
Age Ageing.
1989 Jul.
Abstract
Pharmacological manipulation of central cholinergic neurotransmission may prove beneficial in the treatment of Alzheimer's disease (AD). Tacrine hydrochloride is a central anticholinesterase which has been said to improve intellectual function in patients with AD. We report here our clinical experience with this drug in eight patients with AD, diagnosed according to DSM III and NINCDS-ADRDA criteria. Cholinergic side-effects occurred in five patients, three of whom tolerated a reduced dose. Liver function tests rose within the normal range in all patients and became abnormal in one.
Similar articles
-
Alzheimer's disease: how to give and monitor tacrine therapy.Geriatrics. 1995 May;50(5):50-3. Geriatrics. 1995. PMID: 7737527
-
Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la Tetrahydroaminoacridine.BMJ. 1990 Feb 24;300(6723):495-9. doi: 10.1136/bmj.300.6723.495. BMJ. 1990. PMID: 2107926 Free PMC article. Clinical Trial.
-
Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease.Clin Pharmacol Ther. 1993 Jun;53(6):691-5. doi: 10.1038/clpt.1993.91. Clin Pharmacol Ther. 1993. PMID: 8513661 Clinical Trial.
-
Tacrine in the treatment of Alzheimer's disease. A clinical update and recent pharmacologic studies.Eur Neurol. 1989;29 Suppl 3:28-32. doi: 10.1159/000116478. Eur Neurol. 1989. PMID: 2693104 Review.
-
[Tacrine: progress in treatment of Alzheimer's disease?].Z Gerontol Geriatr. 1995 May-Jun;28(3):163-8. Z Gerontol Geriatr. 1995. PMID: 7664190 Review. German.
Cited by
-
Neuroprotective Effect of Zataria Multiflora Essential Oil on Rats With Alzheimer Disease: A Mechanistic Study.Basic Clin Neurosci. 2019 Jan-Feb;10(1):85-97. doi: 10.32598/bcn.9.10.270. Epub 2019 Jan 1. Basic Clin Neurosci. 2019. PMID: 31031896 Free PMC article.
-
Intracellular pH alterations induced by tacrine in a rat liver biliary epithelial cell line.Br J Pharmacol. 1999 Dec;128(8):1673-82. doi: 10.1038/sj.bjp.0702972. Br J Pharmacol. 1999. PMID: 10588922 Free PMC article.
-
Medicine in the elderly.Postgrad Med J. 1991 May;67(787):423-45. doi: 10.1136/pgmj.67.787.423. Postgrad Med J. 1991. PMID: 1852662 Free PMC article. Review. No abstract available.
-
Clinical pharmacokinetics of drugs for Alzheimer's disease.Clin Pharmacokinet. 1995 Aug;29(2):110-29. doi: 10.2165/00003088-199529020-00005. Clin Pharmacokinet. 1995. PMID: 7586900 Review.
-
Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles.Nanomaterials (Basel). 2020 Oct 21;10(10):2089. doi: 10.3390/nano10102089. Nanomaterials (Basel). 2020. PMID: 33096919 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
