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. 2016 Feb 24;55(9):3208-11.
doi: 10.1002/anie.201510705. Epub 2016 Feb 2.

Cobalt(III)-Catalyzed Redox-Neutral Synthesis of Unprotected Indoles Featuring an N-N Bond Cleavage

Andreas Lerchen  1 , Suhelen Vásquez-Céspedes  1 , Frank Glorius  2
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Cobalt(III)-Catalyzed Redox-Neutral Synthesis of Unprotected Indoles Featuring an N-N Bond Cleavage

Andreas Lerchen et al. Angew Chem Int Ed Engl. .

Abstract

A redox-neutral cobalt(III)-catalyzed synthetic approach for the direct synthesis of unprotected indoles showcasing an N-N bond cleavage is reported. The herein newly introduced Boc-protected hydrazines establish a beneficial addition to the limited portfolio of oxidizing directing groups for cobalt(III) catalysis. Moreover, the developed catalytic methodology tolerates a good variety of functional groups.

Keywords: Cp*CoIII catalysis; C−H activation; N-N bond cleavage; indoles; redox-neutral.

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