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Review
. 2016 Jan;10(1):1-9.

Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants

Sepideh Zununi Vahed, Nasser Samadi, Elmira Mostafidi, Mohammad Reza Ardalan  1 , Yadollah Omidi
Affiliations
  • PMID: 26837673
Review

Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants

Sepideh Zununi Vahed et al. Iran J Kidney Dis. 2016 Jan.

Abstract

Chronic allograft dysfunction is the most common cause of allograft lost. Chronic allograft dysfunction happens as a result of complex interactions at the molecular and cellular levels. Genetic and environmental factors both influence the evolution and progression of the chronic allograft dysfunction. Epigenetic modification could be considered as a therapeutically modifiable element to pause the fibrosis process through novel strategies. In this review, the PubMed database was searched for English-language articles on these new areas.

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