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Randomized Controlled Trial
. 2016 Feb 3:22:362-6.
doi: 10.12659/msm.896586.

Use of Optical Fiber Imported Intra-Tissue Photodynamic Therapy for Treatment of Moderate to Severe Acne Vulgaris

Qian Wang  1 , Dan Yuan  2 , Wei Liu  1 , Jin Chen  1 , Xinyu Lin  1 , Shi Cheng  1 , Fumin Li  1 , Xiling Duan  1
Affiliations
Randomized Controlled Trial

Use of Optical Fiber Imported Intra-Tissue Photodynamic Therapy for Treatment of Moderate to Severe Acne Vulgaris

Qian Wang et al. Med Sci Monit. .

Abstract

Background: To treat moderate to severe acne vulgaris, we developed an optical fiber imported intra-tissue photodynamic therapy: the optical fiber irradiation 5-aminolevulinic acid photodynamic therapy (OFI-ALA-PDT). The aim of this study was to compare the treatment effect and tolerability of OFI-ALA-PDT versus traditional ALA-PDT in the treatment of moderate to severe acne vulgaris.

Material/methods: 60 patients with facial acne enrolled into this study were randomly divided into an OFI-ALA-PDT group and a traditional ALA-PDT group, with 30 patients in each group. The difference between these 2 groups was the red light irradiation methods used. In the OFI-ALA-PDT group we used intra-tissue irradiation (import the red light directly into the target lesion with optical fiber) for 5 min, while the traditional ALA-PDT group received whole-face irradiation for 20 min. All patients received 1 irradiation every 7 to 10 days for a total of 6 irradiations. Treatment effects and adverse reactions were recorded after the 4th and 6th irradiation, and at 4, 8, 16 weeks after the entire treatment.

Results: After the 4th irradiation, significantly different effective rates were observed in these groups (90.0% for the OFI-ALA-PDT group and 66.7% for the control group). However, no significant difference in effective rate was recorded in the later observations. There were 182 adverse reactions in the OFI-ALA-PDT group and 497 in the control group, which showed a significant difference (P<0.05).

Conclusions: OFI-ALA-PDT showed improved treatment effective rate in the early stage of irradiation, and it had fewer adverse reactions.

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Figures

Figure 1
Figure 1
Illustration of intra-tissue OFI-ALA-PDT. The red light was imported directly into the target lesion with optical fiber.
Figure 2
Figure 2
Clinical photographs from a patient treated with OFI-ALA-PDT. (A) Before treatment. (B, C) After the fourth and sixth treatment. (D–F) Follow up at week 4, 8, 16.
See this image and copyright information in PMC

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