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Review
. 2016:2016:8043792.
doi: 10.1155/2016/8043792. Epub 2015 Dec 29.

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Caterina Oriana Aragona  1 , Egidio Imbalzano  1 , Federica Mamone  1 , Valentina Cairo  1 , Alberto Lo Gullo  1 , Angela D'Ascola  2 , Maria Adriana Sardo  1 , Michele Scuruchi  2 , Giorgio Basile  1 , Antonino Saitta  1 , Giuseppe Mandraffino  1
Affiliations
Review

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Caterina Oriana Aragona et al. Stem Cells Int. 2016.

Abstract

Objective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies. Data Sources. MEDLINE was searched using keywords related to "endothelial progenitor cells" and "endothelium" and, for the different categories, respectively, "smoking"; "blood pressure"; "diabetes mellitus" or "insulin resistance"; "dyslipidemia"; "aging" or "elderly"; "angina pectoris" or "myocardial infarction"; "stroke" or "cerebrovascular disease"; "homocysteine"; "C-reactive protein"; "vitamin D". Study Selection. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 quantitative studies were included. Data Syntheses. EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers. Conclusions. EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings. Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. This trial is registered with registration number: Prospero CRD42015023717.

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Figures

Figure 1
Figure 1
Flow diagram for patients exclusion.
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