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Review
. 2016 Jan 25;8(2):77-85.
doi: 10.4253/wjge.v8.i2.77.

Drug eluting biliary stents to decrease stent failure rates: A review of the literature

Joseph Shatzel  1 , Jisoo Kim  1 , Kartik Sampath  1 , Sharjeel Syed  1 , Jennifer Saad  1 , Zilla H Hussain  1 , Kabir Mody  1 , J Marc Pipas  1 , Stuart Gordon  1 , Timothy Gardner  1 , Richard I Rothstein  1
Affiliations
Review

Drug eluting biliary stents to decrease stent failure rates: A review of the literature

Joseph Shatzel et al. World J Gastrointest Endosc. .

Abstract

Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy.

Keywords: Bile ducts; Cholangiocarcinoma; Endoscopy; Pancreas.

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Figures

Figure 1
Figure 1
Change in biliary flow determined by stent radius, as described by Poiseuille's law (A) and laminar flow of viscous fluids (B). Flow= (π • pressure difference • radius4)/(8 • viscosity • length).
See this image and copyright information in PMC

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