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Comment
. 2016 Feb 11;530(7589):164-5.
doi: 10.1038/nature16875. Epub 2016 Feb 3.

Ageing: Out with the old

Jesús Gil  1 , Dominic J Withers  1
Affiliations
Comment

Ageing: Out with the old

Jesús Gil et al. Nature. .
No abstract available

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Figures

Figure 1
Figure 1. Improving healthspan.
As mice age p16Ink4a positive senescent cells accumulate in various organs causing impaired cellular and tissue function leading to age-related pathology. Selective ablation of the accumulating senescent cells using a transgenic mouse with a drug-inducible caspase under the control of a portion of the p16Ink4a promoter results in increased lifespan and healthspan with reduction in a range of age-related pathologies.
See this image and copyright information in PMC

Comment on

  • Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
    Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.

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    1. van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509:439–446. doi: 10.1038/nature13193. - DOI - PMC - PubMed

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