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. 2016 Feb 3;11(2):e0147565.
doi: 10.1371/journal.pone.0147565. eCollection 2016.

Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study

Masatoshi Teraguchi  1 , Noriko Yoshimura  2 , Hiroshi Hashizume  1 , Shigeyuki Muraki  2 , Hiroshi Yamada  1 , Hiroyuki Oka  3 , Akihito Minamide  1 , Yuyu Ishimoto  1 , Keiji Nagata  1 , Ryohei Kagotani  1 , Sakae Tanaka  4 , Hiroshi Kawaguchi  5 , Kozo Nakamura  6 , Toru Akune  6 , Munehito Yoshida  1
Affiliations

Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study

Masatoshi Teraguchi et al. PLoS One. .

Abstract

Objective: The objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD).

Design: The present study included 928 participants (308 men, 620 women) of the 1,011 participants in the Wakayama Spine Study. DD on magnetic resonance imaging was classified according to the Pfirrmann system. OW, HT, DL, and IGT were assessed using the criteria of the Examination Committee of Criteria for MS in Japan.

Results: Multivariable logistic regression analysis revealed that OW was significantly associated with cervical, thoracic, and lumbar DD (cervical: odds ratio [OR], 1.28; 95% confidence interval [CI], 0.92-1.78; thoracic: OR, 1.75; 95% CI, 1.24-2.51; lumbar: OR, 1.87; 95% CI, 1.06-3.48). HT and IGT were significantly associated with thoracic DD (HT: OR, 1.54; 95% CI, 1.09-2.18; IGT: OR, 1.65; 95% CI, 1.12-2.48). Furthermore, subjects with 1 or more MS components had a higher OR for thoracic DD compared with those without MS components (vs. no component; 1 component: OR, 1.58; 95% CI, 1.03-2.42; 2 components: OR, 2.60; 95% CI, 1.62-4.20; ≥3 components: OR, 2.62; 95% CI, 1.42-5.00).

Conclusion: MS components were significantly associated with thoracic DD. Furthermore, accumulation of MS components significantly increased the OR for thoracic DD. These findings support the need for further studies of the effects of metabolic abnormality on DD.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. ORs of the number of MS components for the presence of DD in the thoracic region, compared with no components present.
Subjects with 1 or more MS components had a higher OR for presence of DD compared with those without MS components.
See this image and copyright information in PMC

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