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Case Reports
. 2017 Jan;32(1):190-194.
doi: 10.3904/kjim.2015.107. Epub 2016 Feb 3.

Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer

Affiliations
Case Reports

Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer

Sung Young Moon et al. Korean J Intern Med. 2017 Jan.
No abstract available

Keywords: Breast neoplasms; Pulmonary heart disease; Thrombi.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
Computed tomography showed multiple centrilobular nodules with tree-in-bud appearances in cases 1, 2. A mediastinal setting showed a dilated right ventricle and a compressed D-shaped left ventricle in cases 1 and 2, respectively (A, C). A lung setting showed multiple ill-defined centrilobular nodules with tree-in-bud appearances in cases 1 and 2, respectively (B, D).
Figure 2.
Figure 2.
Echocardiography in case 2. (A) Parasternal short axis view, mid-ventricular plane on transthoracic echocardiography reveals a D-shaped LV throughout the systolic and diastolic period. (B) The 2-dimensional and color Doppler comparative focused image of the apical 4-chamber view showed mild-to-moderate tricuspid regurgitation. (C) The peak tricuspid regurgitation velocity was 3.7 m/sec, pressure gradient 55 mmHg, indicating pulmonary hypertension. (D) The dilated inferior vena cava (IVC) diameter in case 1 was 21 mm without inspiratory collapse. RV, right ventricle; LV, left ventricle.

References

    1. von Herbay A, Illes A, Waldherr R, Otto HF. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer. 1990;66:587–592. - PubMed
    1. Montero A, Vidaller A, Mitjavila F, Chivite D, Pujol R. Microscopic pulmonary tumoral embolism and subacute cor pulmonale as the first clinical signs of cancer. Acta Oncol. 1999;38:1116–1118. - PubMed
    1. Uruga H, Fujii T, Kurosaki A, et al. Pulmonary tumor thrombotic microangiopathy: a clinical analysis of 30 autopsy cases. Intern Med. 2013;52:1317–1323. - PubMed
    1. Miyano S, Izumi S, Takeda Y, et al. Pulmonary tumor thrombotic microangiopathy. J Clin Oncol. 2007;25:597–599. - PubMed
    1. Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest. 2005;115:2811–2821. - PMC - PubMed

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