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. 2015;10(10):1155-1162.
doi: 10.2217/fvl.15.80.

EBV glycoproteins: where are we now?

Lindsey M Hutt-Fletcher  1
Affiliations

EBV glycoproteins: where are we now?

Lindsey M Hutt-Fletcher. Future Virol. 2015.

Abstract

Glycoproteins are critical to virus entry, to spread within and between hosts and can modify the behavior of cells. Many viruses carry only a few, most found in the virion envelope. EBV makes more than 12, providing flexibility in how it colonizes its human host. Some are dedicated to getting the virus through the cell membrane and on toward the nucleus of the cell, some help guide the virus back out and on to the next cell in the same or a new host. Yet others undermine host defenses helping the virus persist for a lifetime, maintaining a presence that is mostly tolerated and serves to perpetuate EBV as one of the most common infections of man.

Keywords: B cells; assembly; attachment; egress; epithelial cells; fusion; immune evasion.

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Conflict of interest statement

Financial & competing interests disclosure

The author received grants (AI020662, DE016669 & AI0161017) from the US NIH in support of the work discussed within this article. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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