Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:6573215.
doi: 10.1155/2016/6573215. Epub 2015 Dec 30.

Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility among Diabetic Patients with Controlled and Uncontrolled Glycemia in Kuwait

May Sewify  1 , Shinu Nair  1 , Samia Warsame  2 , Mohamed Murad  1 , Asma Alhubail  1 , Kazem Behbehani  3 , Faisal Al-Refaei  1 , Ali Tiss  2
Affiliations

Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility among Diabetic Patients with Controlled and Uncontrolled Glycemia in Kuwait

May Sewify et al. J Diabetes Res. 2016.

Abstract

Diabetic patients have higher risk of urinary tract infection (UTI). In the present study, we investigated the impact of glycemic control in diabetic patients on UTI prevalence, type of strains, and their antimicrobial drugs susceptibility. This study was conducted on urine samples from 722 adult diabetic patients from which 252 (35%) samples were positive for uropathogens. Most UTI cases occurred in the uncontrolled glycemic group (197 patients) versus 55 patients with controlled glycemia. Higher glycemic levels were measured in uncontrolled glycemia group (HbA1c = 8.3 ± 1.5 and 5.4 ± 0.4, resp., P < 0.0001). Females showed much higher prevalence of UTI than males in both glycemic groups (88.5% and 11.5%, resp., P < 0.0001). In the uncontrolled glycemia group 90.9% of the UTI cases happened at ages above 40 years and a clear correlation was obtained between patient age ranges and number of UTI cases (r = 0.94; P = 0.017), whereas in the group with controlled glycemia no trend was observed. Escherichia coli was the predominant uropathogen followed by Klebsiella pneumoniae and they were together involved in 76.2% of UTI cases. Those species were similarly present in both diabetic groups and displayed comparable antibiotic resistance pattern. These results highlight the importance of controlling glycemia in diabetic patients to reduce the UTI regardless of age and gender.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of UTI cases according to age ranges and glycemic status of our diabetic patients.
Figure 2
Figure 2
Distribution of most UTI prevalent pathogens in our study population groups.
Figure 3
Figure 3
Resistance pattern for most UTI prevalent Gram-negative and Gram-positive pathogens in all population study.
See this image and copyright information in PMC

References

    1. Kunin C. M. Chemoprophylaxis and suppressive therapy in the management of urinary tract infections. Journal of Antimicrobial Chemotherapy. 1994;33(supplement A):51–62. doi: 10.1093/jac/33.suppl_a.51. - DOI - PubMed
    1. Gupta K., Sahm D. F., Mayfield D., Stamm W. E. Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in women: a nationwide analysis. Clinical Infectious Diseases. 2001;33(1):89–94. doi: 10.1086/320880. - DOI - PubMed
    1. de Lastours V., Foxman B. Urinary tract infection in diabetes: epidemiologic considerations. Current Infectious Disease Reports. 2014;16(1, article 389) doi: 10.1007/s11908-013-0389-2. - DOI - PubMed
    1. Patterson J. E., Andriole V. T. Bacterial urinary tract infections in diabetes. Infectious Disease Clinics of North America. 1997;11(3):735–750. doi: 10.1016/S0891-5520(05)70383-4. - DOI - PubMed
    1. Saleem M., Daniel B. Prevalence of urinary tract infection among patients with diabetes in Bangalore city. International Journal of Emerging Sciences. 2011;1(2):133–142.

MeSH terms