Reply

Christine E McLaren¹, James C Barton², V Nathan Subramaniam^{3

4}, Grant A Ramm^{3

4}, Pradyumna D Phatak⁵, Mary J Emond⁶, Lyle C Gurrin⁷, Paul C Adams⁸, Lawrie W Powell^{3

4

9}, Gregory J Anderson^{3

10}, Gordon D McLaren^{11

12}

Affiliations

¹ Department of Epidemiology, University of California, Irvine, CA.
² Southern Iron Disorders Center, Birmingham, AL.
³ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
⁴ Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, Australia.
⁵ Rochester General Hospital, Rochester, NY.
⁶ Department of Biostatistics, University of Washington, Seattle, WA.
⁷ Center for MEGA Epidemiology, The University of Melbourne, Melbourne, Australia.
⁸ Department of Medicine, London Health Sciences Center, London, Ontario, Canada.
⁹ Royal Brisbane & Women's Hospital, Brisbane, Australia.
¹⁰ School of Medicine and School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia.
¹¹ Department of Veterans Affairs Long Beach Healthcare System, Long Beach, CA.
¹² Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, CA.

Comment

Christine E McLaren et al. Hepatology. 2016 Jun.

. 2016 Jun;63(6):2058-60.

doi: 10.1002/hep.28479. Epub 2016 Mar 15.

¹ Department of Epidemiology, University of California, Irvine, CA.
² Southern Iron Disorders Center, Birmingham, AL.
³ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
⁴ Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, Australia.
⁵ Rochester General Hospital, Rochester, NY.
⁶ Department of Biostatistics, University of Washington, Seattle, WA.
⁷ Center for MEGA Epidemiology, The University of Melbourne, Melbourne, Australia.
⁸ Department of Medicine, London Health Sciences Center, London, Ontario, Canada.
⁹ Royal Brisbane & Women's Hospital, Brisbane, Australia.
¹⁰ School of Medicine and School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia.
¹¹ Department of Veterans Affairs Long Beach Healthcare System, Long Beach, CA.
¹² Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, CA.

No abstract available

Comment on

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.
McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, Goh JB, McDonald CJ, Powell LW, Gurrin LC, Allen KJ, Nickerson DA, Louie T, Ramm GA, Anderson GJ, McLaren GD. McLaren CE, et al. Hepatology. 2015 Aug;62(2):429-39. doi: 10.1002/hep.27711. Epub 2015 Mar 18. Hepatology. 2015. PMID: 25605615 Free PMC article.
GNPAT variant is associated with iron phenotype in healthy Taiwanese women: A population without the HFE C282Y mutation.
Hsiao SC, Lee CT, Pei SN. Hsiao SC, et al. Hepatology. 2016 Jun;63(6):2057-8. doi: 10.1002/hep.28481. Epub 2016 Mar 10. Hepatology. 2016. PMID: 26845415 No abstract available.

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1. McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, et al. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology. 2015;62:429–439. - PMC - PubMed
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