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Review
. 2016 Apr;28(2):202-8.
doi: 10.1097/MOP.0000000000000323.

Proteinuria and hematuria in the neonate

Catherine Joseph  1 , Jyothsna Gattineni
Affiliations
Review

Proteinuria and hematuria in the neonate

Catherine Joseph et al. Curr Opin Pediatr. 2016 Apr.

Abstract

Purpose of review: Neonatal proteinuria and hematuria while not common can have potentially devastating consequences if left undiagnosed and untreated. It is important to distinguish between inherited and acquired causes of proteinuria to initiate appropriate and timely treatment. With regards to hematuria, it is critical to identify true hematuria from pseudo-hematuria to balance between thorough investigation and unnecessary laboratory work up. This review provides an overview of the common causes of hematuria and proteinuria in a neonate.

Recent findings: The identification of genetic mutations in nephrotic syndrome has improved our understanding of the role of various proteins that play an important role in maintaining the glomerular filtration barrier. With the advancement in our ability to provide care for extreme premature neonates, the incidence of acute kidney injury has increased in these neonates along with proteinuria and hematuria.

Summary: Persistent proteinuria after neonatal acute kidney injury would be of interest in regards to the risk of developing future chronic kidney disease and hypertension.

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Conflict of interest statement

Conflicts of Interest:

The authors have no conflicts of interest.

References

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