Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Feb 5;118(3):374-6.
doi: 10.1161/CIRCRESAHA.115.308190.

Blood-Derived Extracellular RNA and Platelet Pathobiology: Adding Pieces to a Complex Circulating Puzzle

Lauren Clancy  1 , Jane E Freedman  2
Affiliations
Editorial

Blood-Derived Extracellular RNA and Platelet Pathobiology: Adding Pieces to a Complex Circulating Puzzle

Lauren Clancy et al. Circ Res. .
No abstract available

Keywords: Editorial; diabetes mellitus; microRNA; platelet; thrombosis; transcriptomics.

PubMed Disclaimer

Figures

None
The Connection Between Plasma and Platelet microRNAs
Platelets transfer microRNA (miRNA) and other coding and noncoding RNAs both through direct transfer and via exosome release where it can be detected in the plasma. The transfer of these miRNAs leads to altered vascular cellular phenotypes including changes in platelet proteins and platelet function (platelet image courtesy of Olga Vitseva).
See this image and copyright information in PMC

Comment on

  • Association of MicroRNAs and YRNAs With Platelet Function.
    Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Kaudewitz D, et al. Circ Res. 2016 Feb 5;118(3):420-432. doi: 10.1161/CIRCRESAHA.114.305663. Epub 2015 Dec 8. Circ Res. 2016. PMID: 26646931 Free PMC article.

References

    1. Clancy L, Freedman JE. The role of circulating platelet transcripts. Journal of thrombosis and haemostasis : JTH. 2015;13(Suppl 1):S33–S39. - PubMed
    1. Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD, Benjamin EJ. Relation of platelet and leukocyte inflammatory transcripts to body mass index in the framingham heart study. Circulation. 2010;122:119–129. - PMC - PubMed
    1. Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Platelet-tlr7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood. 2014;124:791–802. - PMC - PubMed
    1. Risitano A, Beaulieu LM, Vitseva O, Freedman JE. Platelets and platelet-like particles mediate intercellular rna transfer. Blood. 2012;119:6288–6295. - PMC - PubMed
    1. Gidlof O, van der Brug M, Ohman J, Gilje P, Olde B, Wahlestedt C, Erlinge D. Platelets activated during myocardial infarction release functional mirna, which can be taken up by endothelial cells and regulate icam1 expression. Blood. 2013;121:3908–3917. S3901–S3926. - PubMed

LinkOut - more resources