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Review
. 2016 Mar;16(3):26.
doi: 10.1007/s11910-016-0626-9.

Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders

Meredith C Frederick  1   2 , Michelle H Cameron  3   4
Affiliations
Review

Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders

Meredith C Frederick et al. Curr Neurol Neurosci Rep. 2016 Mar.

Abstract

Tumefactive demyelinating lesions are rare consequences of central nervous system (CNS) idiopathic inflammatory demyelinating diseases. Tumefactive demyelinating lesions pose a diagnostic challenge because they can mimic tumors and abscesses and because they can be caused by a heterogeneous range of disorders. This article reviews the recent literature on the clinical presentation; radiographic features; prognosis; and management of tumefactive demyelinating lesions in multiple sclerosis, acute demyelinating encephalomyelitis, neuromyelitis optica, and the rare variants of multiple sclerosis including Schilder's disease, Marburg acute multiple sclerosis, and Balo's concentric sclerosis.

Keywords: Balo’s concentric sclerosis; Marburg; Schilder’s disease; Tumefactive multiple sclerosis.

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