Assessment of brain temperatures during different phases of the menstrual cycle using diffusion-weighted imaging thermometry

Abstract

Purpose: To investigate changes in brain temperature according to the menstrual cycle in women using diffusion-weighted imaging (DWI) thermometry and to clarify relationships between brain and body temperatures.

Materials and methods: In 20 healthy female volunteers (21.3-38.8 years), DWI of the brain was performed during the follicular and luteal phases to calculate the brain temperature. During DWI, body temperatures were also measured. Group comparisons of each temperature between the two phases were performed using the paired t test. Correlations between brain and body temperatures were analyzed using Pearson's correlation coefficient test.

Results: Mean diffusion-based brain temperature was 36.24 °C (follicular) and 36.96 °C (luteal), showing a significant difference (P < 0.0001). Significant differences were also seen for each body temperature between the two phases. Correlation coefficients between diffusion-based brain and each body temperature were r = 0.2441 (P = 0.1291), -0.0332 (0.8387), and -0.0462 (0.7769), respectively.

Conclusions: In women of childbearing age, brain and body temperatures appear significantly higher in the luteal than in the follicular phase. However, brain and body temperatures show no significant correlations.

Keywords: Brain temperature; Diffusion-weighted imaging; Menstrual cycle; Thermometry.