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. 1989 Nov 30;83(2):271-9.
doi: 10.1016/0378-1119(89)90113-3.

The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth

E Balzi  1 , W N Chen, E Capieaux, J H McCusker, J E Haber, A Goffeau
Affiliations

The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth

E Balzi et al. Gene. .

Erratum in

  • Gene 1990 Apr 30;89(1):151

Abstract

In Saccharomyces cerevisiae, the SCL-1 mutation is a dominant suppressor of the cycloheximide-resistant, temperature-sensitive (ts) lethal mutation, crl3 [McCusker and Haber, Genetics 119 (1988a) 303-315]. The wild-type scl1+ gene was isolated by screening subclones of the 35-kb region between TRP5 and LEU1 for restoration of the ts phenotype in an SCL1-1 crl3-2 strain. The scl1+ mRNA is about 900 nt long and encodes an open reading frame of 810 bp. The polypeptide deduced from scl1+ possesses a putative secretory signal peptide. The 5'-noncoding region may be under multiple controls, since it contains significant homology to the consensus sequences for the DNA-binding proteins, GCN4, GFI and, possibly, TUF. Gene disruption of scl1+ demonstrates that it is an essential gene.

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