Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Oct 1:22:87.
doi: 10.11604/pamj.2015.22.87.6037. eCollection 2015.

Susceptibility pattern of uropathogens to ciprofloxacin at the Ghana police hospital

Daniel Kwame Afriyie  1 , Martha Gyansa-Lutterodt  2 , Seth Kwabena Amponsah  3 , George Asare  4 , Vanessa Wiredu  1 , Edem Wormenor  1 , Kwasi Agyei Bugyei  3
Affiliations

Susceptibility pattern of uropathogens to ciprofloxacin at the Ghana police hospital

Daniel Kwame Afriyie et al. Pan Afr Med J. .

Abstract

Introduction: Reports of increasing resistance of uropathogens to antimicrobials is of global concern. Culture and drug susceptibility tests remain a vital guide to effective therapy. The aim of this study was to determine the susceptibility pattern of isolated uropathogens to ciprofloxacin at the Ghana Police Hospital.

Methods: A total of 705 mid-stream urine samples were collected from patients suspected of having urinary tract infection, and visited the Ghana Police Hospital's laboratory from December 2013 to March 2014. Samples were cultured and isolates identified by standard methods, after which isolates susceptibility to ciprofloxacin was determined.

Results: Prevalence of urinary tract infection among patients' whose samples were analyzed was 15.9%. Predominant uropathogens isolated were E. coli (46.4%), Coliform (41.1%) and Coliform spp. with Candida (6.2%). Other isolates were Pseudomonas spp. (2.7%), Salmonella spp. (1.8%), Candida spp. (0.9%) and Klebsiella spp (0.9%). The overall resistance among the top three isolated uropathogens to ciprofloxacin was 35.9%. Resistance pattern demonstrated by respective isolates to ciprofloxacin were: E. coli (38.5%), Coliform (54.3%), and Coliform spp. with Candida (15%). The other isolates showed 100% sensitivity.

Conclusion: This study revealed a relatively high ciprofloxacin resistance among isolated uropathogens, hence, the need for prudent prescribing and use of ciprofloxacin in urinary tract infection management.

Keywords: Urinary tract infection; antibiotics; isolates; susceptibility; uropathogens.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Foxman B, Brown P. Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs. Infect Dis Clin North Am. 2003;17(2):227–24. - PubMed
    1. Gupta K. Addressing antibiotic resistance. Dis Mon. 2003;49(2):99–110. - PubMed
    1. Adjei O, Opoku C. Urinary tract infections in African infants. Int J Antimicrob Agents. 2004;24(1):32–34. - PubMed
    1. Boye A, Siakwa PM, Boampong JN, Koffour GA, Ephraim RKD, Amoateng P, Obodai G, Penu D. Asymptomatic urinary tract infections in pregnant women attending antenatal clinic in Cape Coast, Ghana. J Med Res. 2012;1(6):74–83.
    1. Onoh RC, Umeora OUJ, Egwuatu VE, Ezeonu PO, Onoh TJP. Antibiotic sensitivity pattern of uropathogens from pregnant women with urinary tract infection in Abakaliki, Nigeria. Infect Drug Resist. 2013;6:225–233. - PMC - PubMed